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光声血氧定量法实现了光谱去色。

Learned spectral decoloring enables photoacoustic oximetry.

机构信息

Computer Assisted Medical Interventions, German Cancer Research Center, Heidelberg, Germany.

Medical Faculty, Heidelberg University, Heidelberg, Germany.

出版信息

Sci Rep. 2021 Mar 22;11(1):6565. doi: 10.1038/s41598-021-83405-8.

DOI:10.1038/s41598-021-83405-8
PMID:33753769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7985523/
Abstract

The ability of photoacoustic imaging to measure functional tissue properties, such as blood oxygenation sO[Formula: see text], enables a wide variety of possible applications. sO[Formula: see text] can be computed from the ratio of oxyhemoglobin HbO[Formula: see text] and deoxyhemoglobin Hb, which can be distuinguished by multispectral photoacoustic imaging due to their distinct wavelength-dependent absorption. However, current methods for estimating sO[Formula: see text] yield inaccurate results in realistic settings, due to the unknown and wavelength-dependent influence of the light fluence on the signal. In this work, we propose learned spectral decoloring to enable blood oxygenation measurements to be inferred from multispectral photoacoustic imaging. The method computes sO[Formula: see text] pixel-wise, directly from initial pressure spectra [Formula: see text], which represent initial pressure values at a fixed spatial location [Formula: see text] over all recorded wavelengths [Formula: see text]. The method is compared to linear unmixing approaches, as well as pO[Formula: see text] and blood gas analysis reference measurements. Experimental results suggest that the proposed method is able to obtain sO[Formula: see text] estimates from multispectral photoacoustic measurements in silico, in vitro, and in vivo.

摘要

光声成像是一种能够测量血氧饱和度 sO[Formula: see text]等功能组织特性的技术，这使得它在很多领域都有广泛的应用。sO[Formula: see text]可以通过血红蛋白 HbO[Formula: see text]和脱氧血红蛋白 Hb 的比例来计算，由于它们在不同波长下的吸收特性不同，多光谱光声成像可以区分这两种物质。然而，由于光在信号中的未知和波长依赖性影响，目前用于估计 sO[Formula: see text]的方法在实际环境中会产生不准确的结果。在这项工作中，我们提出了基于学习的光谱去色，以便能够从多光谱光声成像中推断出血氧饱和度的测量值。该方法直接从初始压力光谱 [Formula: see text]计算 sO[Formula: see text]，[Formula: see text]表示在所有记录的波长 [Formula: see text]下固定空间位置 [Formula: see text]处的初始压力值。该方法与线性解混方法以及 pO[Formula: see text]和血气分析参考测量值进行了比较。实验结果表明，该方法能够从多光谱光声测量中获得 sO[Formula: see text]的估计值，无论是在计算机模拟、体外实验还是体内实验中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/7c5228abe564/41598_2021_83405_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/c78a2d15b620/41598_2021_83405_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/53a191311513/41598_2021_83405_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/a4ba754c42aa/41598_2021_83405_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/50cc796be161/41598_2021_83405_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/0de6e8df1287/41598_2021_83405_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/087e24973a27/41598_2021_83405_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/342c21bf992a/41598_2021_83405_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/999f7f36e7ea/41598_2021_83405_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/7c5228abe564/41598_2021_83405_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/c78a2d15b620/41598_2021_83405_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/53a191311513/41598_2021_83405_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/a4ba754c42aa/41598_2021_83405_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/50cc796be161/41598_2021_83405_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/0de6e8df1287/41598_2021_83405_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/087e24973a27/41598_2021_83405_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/342c21bf992a/41598_2021_83405_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/999f7f36e7ea/41598_2021_83405_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee87/7985523/7c5228abe564/41598_2021_83405_Fig9_HTML.jpg

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