细胞外囊泡在免疫调节和肿瘤进展中的作用。
Extracellular vesicles in immunomodulation and tumor progression.
机构信息
Institute for NanoBiotechnology (INBT), The Johns Hopkins University, Baltimore, MD, USA.
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.
出版信息
Nat Immunol. 2021 May;22(5):560-570. doi: 10.1038/s41590-021-00899-0. Epub 2021 Mar 22.
Abstract
Extracellular vesicles have emerged as prominent regulators of the immune response during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a critical role in immunomodulation. Here, we identify the role of EVs as mediators of communication between cancer and immune cells. This expanded role of EVs may shed light on the mechanisms behind tumor progression and provide translational diagnostic and prognostic tools for immunologists.
摘要
细胞外囊泡在肿瘤进展过程中作为免疫反应的重要调节因子而备受关注。EVs 包含多样化的分子货物，这些货物在免疫调节中起着关键作用。在这里，我们确定了 EVs 作为癌细胞与免疫细胞之间通讯媒介的作用。EVs 的这种扩展作用可能揭示肿瘤进展背后的机制，并为免疫学家提供转化诊断和预后工具。
相似文献
1
Extracellular vesicles in immunomodulation and tumor progression.细胞外囊泡在免疫调节和肿瘤进展中的作用。
Nat Immunol. 2021 May;22(5):560-570. doi: 10.1038/s41590-021-00899-0. Epub 2021 Mar 22.
2
How cancer cells dictate their microenvironment: present roles of extracellular vesicles.癌细胞如何塑造其微环境：细胞外囊泡的当前作用
Cell Mol Life Sci. 2017 Feb;74(4):697-713. doi: 10.1007/s00018-016-2346-3. Epub 2016 Aug 31.
3
Modulatory effects of cancer stem cell-derived extracellular vesicles on the tumor immune microenvironment.肿瘤干细胞衍生的细胞外囊泡对肿瘤免疫微环境的调节作用。
Front Immunol. 2024 Jun 19;15:1362120. doi: 10.3389/fimmu.2024.1362120. eCollection 2024.
4
Tumor-derived extracellular vesicles: Regulators of tumor microenvironment and the enlightenment in tumor therapy.肿瘤细胞外囊泡：肿瘤微环境的调控因子及在肿瘤治疗中的启示。
Pharmacol Res. 2020 Sep;159:105041. doi: 10.1016/j.phrs.2020.105041. Epub 2020 Jun 21.
5
The Yin and Yang of tumour-derived extracellular vesicles in tumour immunity.肿瘤衍生细胞外囊泡在肿瘤免疫中的阴阳两面。
J Biochem. 2021 Mar 5;169(2):155-161. doi: 10.1093/jb/mvaa132.
6
Natural Killer Cell-Derived Extracellular Vesicles: Novel Players in Cancer Immunotherapy.自然杀伤细胞衍生的细胞外囊泡：癌症免疫治疗的新角色。
Front Immunol. 2021 May 21;12:658698. doi: 10.3389/fimmu.2021.658698. eCollection 2021.
7
Engineered small extracellular vesicle-mediated ferroptosis: A new frontier in cancer immunotherapy.工程化小细胞外囊泡介导的铁死亡：癌症免疫治疗的新前沿。
Int Immunopharmacol. 2024 Sep 30;139:112621. doi: 10.1016/j.intimp.2024.112621. Epub 2024 Jul 15.
8
Extracellular vesicles mediated gastric cancer immune response: tumor cell death or immune escape?细胞外囊泡介导的胃癌免疫反应：肿瘤细胞死亡还是免疫逃逸？
Cell Death Dis. 2024 May 30;15(5):377. doi: 10.1038/s41419-024-06758-8.
9
Tumor-derived extracellular vesicles: molecular parcels that enable regulation of the immune response in cancer.肿瘤来源的细胞外囊泡：使癌症免疫反应调控成为可能的分子包裹体。
J Cell Sci. 2019 Oct 15;132(20):jcs235085. doi: 10.1242/jcs.235085.
10
Tumor-Derived Extracellular Vesicles: Multifunctional Entities in the Tumor Microenvironment.肿瘤衍生的细胞外囊泡：肿瘤微环境中的多功能实体。
Annu Rev Pathol. 2023 Jan 24;18:205-229. doi: 10.1146/annurev-pathmechdis-031521-022116. Epub 2022 Oct 6.
引用本文的文献
1
Sophora flavescens-derived extracellular vesicles loaded with oncolytic vaccinia virus/IR1061 for NIR-II photoacoustic imaging guided multimodal treatment of diffuse large B-cell lymphoma.负载溶瘤痘苗病毒/IR1061的苦参衍生细胞外囊泡用于近红外二区光声成像引导的弥漫性大B细胞淋巴瘤多模态治疗。
Mater Today Bio. 2025 Aug 6;34:102177. doi: 10.1016/j.mtbio.2025.102177. eCollection 2025 Oct.
2
Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies.基于细胞外囊泡的药物概述：研究现状、质量控制及非临床评估策略
Signal Transduct Target Ther. 2025 Aug 14;10(1):255. doi: 10.1038/s41392-025-02312-w.
3
Mechanical regulation of extracellular vesicle activity during tumour progression.肿瘤进展过程中细胞外囊泡活性的机械调节
Nat Biomed Eng. 2025 Aug 6. doi: 10.1038/s41551-025-01446-0.
4
ApoBDs: a paradigm shift from cellular debris to therapeutic vehicles.凋亡小体：从细胞碎片到治疗载体的范式转变。
Front Endocrinol (Lausanne). 2025 Jul 17;16:1626796. doi: 10.3389/fendo.2025.1626796. eCollection 2025.
5
Strategic Advances in Targeted Delivery Carriers for Therapeutic Cancer Vaccines.治疗性癌症疫苗靶向递送载体的战略进展
Int J Mol Sci. 2025 Jul 17;26(14):6879. doi: 10.3390/ijms26146879.
6
Extracellular Vesicles for Clinical Diagnostics: From Bulk Measurements to Single-Vesicle Analysis.用于临床诊断的细胞外囊泡：从整体测量到单囊泡分析
ACS Nano. 2025 Aug 12;19(31):28021-28109. doi: 10.1021/acsnano.5c00706. Epub 2025 Jul 28.
7
Plant-derived extracellular vesicles as a natural drug delivery platform for glioblastoma therapy: A dual role in preserving endothelial integrity while modulating the tumor microenvironment.植物源细胞外囊泡作为胶质母细胞瘤治疗的天然药物递送平台：在维持内皮完整性和调节肿瘤微环境方面的双重作用。
Int J Pharm X. 2025 Jun 24;10:100349. doi: 10.1016/j.ijpx.2025.100349. eCollection 2025 Dec.
8
The role of extracellular vesicles in chronic lung allograft dysfunction and response to extracorporeal photopheresis.细胞外囊泡在慢性肺移植功能障碍及体外光化学疗法反应中的作用
JHLT Open. 2025 Jun 15;9:100322. doi: 10.1016/j.jhlto.2025.100322. eCollection 2025 Aug.
9
Mapping the knowledge network of extracellular vesicles and angiogenesis in tumor-immune communication: a scientometric analysis.绘制肿瘤免疫通讯中细胞外囊泡与血管生成的知识网络：一项科学计量学分析
Front Oncol. 2025 Jul 1;15:1568365. doi: 10.3389/fonc.2025.1568365. eCollection 2025.
10
Gardenia-derived extracellular vesicles exert therapeutic effects on dopaminergic neuron apoptosis-mediated Parkinson's disease.栀子来源的细胞外囊泡对多巴胺能神经元凋亡介导的帕金森病具有治疗作用。
NPJ Parkinsons Dis. 2025 Jul 3;11(1):200. doi: 10.1038/s41531-025-01044-6.
本文引用的文献
1
Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells.可视化树突状细胞之间肿瘤抗原的突触传递
Cancer Cell. 2020 Jun 8;37(6):786-799.e5. doi: 10.1016/j.ccell.2020.05.002.
2
Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage.调节性T细胞细胞外囊泡可改变效应T细胞的细胞因子产生并预防人类皮肤移植损伤。
Front Cell Dev Biol. 2020 May 20;8:317. doi: 10.3389/fcell.2020.00317. eCollection 2020.
3
Antitumor immunity by small extracellular vesicles collected from activated dendritic cells through effective induction of cellular and humoral immune responses.通过有效诱导细胞免疫和体液免疫反应，从活化树突状细胞收集的小细胞外囊泡产生的抗肿瘤免疫。
Biomaterials. 2020 Sep;252:120112. doi: 10.1016/j.biomaterials.2020.120112. Epub 2020 May 11.
4
Radiation-induced small extracellular vesicles as "carriages" promote tumor antigen release and trigger antitumor immunity.辐射诱导的小细胞外囊泡作为“载体”促进肿瘤抗原释放并触发抗肿瘤免疫。
Theranostics. 2020 Mar 26;10(11):4871-4884. doi: 10.7150/thno.43539. eCollection 2020.
5
Characterization and antiproliferative activity of glioma-derived extracellular vesicles.胶质瘤衍生细胞外囊泡的鉴定和抗增殖活性。
Nanomedicine (Lond). 2020 Apr;15(10):1001-1018. doi: 10.2217/nnm-2019-0431. Epub 2020 Apr 6.
6
Matrix mechanics and water permeation regulate extracellular vesicle transport.基质力学和水渗透调节细胞外囊泡运输。
Nat Nanotechnol. 2020 Mar;15(3):217-223. doi: 10.1038/s41565-020-0636-2. Epub 2020 Feb 17.
7
Thyrocyte-derived exosome-targeted dendritic cells stimulate strong CD4 T lymphocyte responses.甲状腺细胞来源的外泌体靶向树突状细胞刺激强烈的 CD4 T 淋巴细胞反应。
Mol Cell Endocrinol. 2020 Apr 15;506:110756. doi: 10.1016/j.mce.2020.110756. Epub 2020 Feb 8.
8
Tracking the evolution of circulating exosomal-PD-L1 to monitor melanoma patients.追踪循环外泌体程序性死亡配体1的演变以监测黑色素瘤患者。
J Extracell Vesicles. 2020 Jan 7;9(1):1710899. doi: 10.1080/20013078.2019.1710899. eCollection 2020.
9
Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance.调节性 T 细胞衍生的 IL-35 包被的细胞外囊泡促进感染性耐受。
Cell Rep. 2020 Jan 28;30(4):1039-1051.e5. doi: 10.1016/j.celrep.2019.12.081.
10
The importance of exosomal PDL1 in tumour immune evasion.外泌体 PD-L1 在肿瘤免疫逃逸中的重要性。
Nat Rev Immunol. 2020 Apr;20(4):209-215. doi: 10.1038/s41577-019-0264-y. Epub 2020 Jan 21.
Zotero 插件