Institute for NanoBiotechnology (INBT), The Johns Hopkins University, Baltimore, MD, USA.
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA.
Nat Immunol. 2021 May;22(5):560-570. doi: 10.1038/s41590-021-00899-0. Epub 2021 Mar 22.
Extracellular vesicles have emerged as prominent regulators of the immune response during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a critical role in immunomodulation. Here, we identify the role of EVs as mediators of communication between cancer and immune cells. This expanded role of EVs may shed light on the mechanisms behind tumor progression and provide translational diagnostic and prognostic tools for immunologists.
细胞外囊泡在肿瘤进展过程中作为免疫反应的重要调节因子而备受关注。EVs 包含多样化的分子货物，这些货物在免疫调节中起着关键作用。在这里，我们确定了 EVs 作为癌细胞与免疫细胞之间通讯媒介的作用。EVs 的这种扩展作用可能揭示肿瘤进展背后的机制，并为免疫学家提供转化诊断和预后工具。
