School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Adv Mater. 2021 Apr;33(17):e2100119. doi: 10.1002/adma.202100119. Epub 2021 Mar 22.
Organic neuromorphic devices and sensors that mimic the functions of chemical synapses and sensory perception in humans have received much attention for next-generation computing and integrated logic circuits. Despite recent advances, organic artificial synapses capable of detecting both neurotransmitters in liquid environments and light are not reported. Herein, inspired by hippocampal synapses, a dual-gate organic synaptic transistor platform with a photoconductive polymer semiconductor, a ferroelectric insulator of P(VDF-TrFE), and an extended-gate electrode functionalized with boronic acid is developed to simultaneously detect the neurotransmitter dopamine and light. The developed synaptic transistor enables memory consolidation upon repetitive exposure to dopamine and polychromatic light, exhibiting effectively modulated postsynaptic currents. This proof-of-concept hippocampal-synapse-mimetic organic neuromorphic system combining a chemical sensor and a photosensor opens new possibilities for developing low-power organic artificial synaptic multisensors and light-induced memory consolidative artificial synapses, and can also contribute to the development of human-machine interfaces.
有机神经形态器件和传感器可以模拟人类化学突触和感官感知的功能，因此在下一代计算和集成逻辑电路方面受到了广泛关注。尽管最近取得了一些进展，但能够在液体环境中同时检测神经递质和光的有机人工突触尚未见报道。受海马突触的启发，本研究开发了一种具有光电导聚合物半导体、铁电 P(VDF-TrFE) 电介质和硼酸功能化扩展栅极的双栅有机突触晶体管平台，以同时检测神经递质多巴胺和光。所开发的突触晶体管在重复暴露于多巴胺和多色光下能够实现记忆巩固，表现出有效调制的突触后电流。这种结合化学传感器和光传感器的概念验证型海马突触模拟有机神经形态系统为开发低功耗有机人工突触多传感器和光诱导记忆巩固人工突触开辟了新的可能性，也有助于开发人机接口。
