Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India; Department of Physiology, University of Calcutta, Kolkata, India.
Department of Neurology, Institute of Neurosciences Kolkata, Kolkata, India.
J Neuroimmunol. 2021 May 15;354:577545. doi: 10.1016/j.jneuroim.2021.577545. Epub 2021 Mar 9.
Inflammation along with oxidative stress alters neuroplasticity which might contribute to neurodegeneration in Parkinson's disease (PD).
We aimed to explore the correlation of inflammatory-oxidative and neurotrophic changes in PD and their association with clinical staging and motor severity.
Serum oxidative markers, pro and anti-inflammatory cytokines and BDNF levels were estimated by spectrophotometric and ELISA techniques.
Redox-Inflammatory and neurotrophic markers significantly altered in PD and strongly correlated with motor severity and stagings of PD.
This study establishes a link between peripheral immune-neurotrophic markers and disease severity in PD. This can lead to novel future therapeutics.
炎症和氧化应激改变神经可塑性，这可能导致帕金森病（PD）的神经退行性变。
我们旨在探索 PD 中炎症-氧化和神经营养变化的相关性及其与临床分期和运动严重程度的关系。
通过分光光度法和 ELISA 技术评估血清氧化标志物、促炎和抗炎细胞因子以及 BDNF 水平。
氧化炎症和神经营养标志物在 PD 中明显改变，与运动严重程度和 PD 的分期密切相关。
本研究在 PD 中建立了外周免疫-神经营养标志物与疾病严重程度之间的联系。这可能导致新的未来治疗方法。
