Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Department of Biostatistics, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
J Parkinsons Dis. 2022;12(2):667-678. doi: 10.3233/JPD-212914.
The immune system is known to be involved in Parkinson's disease (PD) pathogenesis, but the temporal relationship between peripheral immune responses and PD remains unknown.
We determined the association between peripheral immune cell numbers, C-reactive protein (CRP), and prevalent as well as incident PD.
This study was embedded in the population-based setting of the Rotterdam Study. We repeatedly measured peripheral immune cell numbers (differential leukocyte count and platelet count, granulocyte-to-lymphocyte ratio [GLR], platelet-to-lymphocyte ratio [PLR], and adapted systemic immune-inflammation index [adapted SII]) and CRP between 1990 and 2016. Participants were continuously followed-up for PD until 2018. We estimated the association of the markers with prevalent and incident PD using logistic regression models and joint models, respectively. Models were adjusted for age, sex, smoking, body mass index, and medication use. Odds ratios (OR) and hazard ratios (HR) are shown per doubling of the marker.
A total of 12,642 participants were included in this study. The mean age (standard deviation) was 65.1 (9.8) years and 57.5%were women. Participants with a higher lymphocyte count were less likely to have prevalent PD (adjusted OR: 0.34, 95%CI 0.17-0.68). Participants with a higher GLR, PLR, and adapted SII were more likely to have prevalent PD, but these effects were explained by the lymphocyte count. The peripheral immune cell numbers and CRP were not significantly associated with the risk of incident PD.
We found participants with a higher lymphocyte count to be less likely to have prevalent PD, but we did not find an association between peripheral immune cell numbers nor CRP and the risk of incident PD.
免疫系统被认为参与了帕金森病（PD）的发病机制，但外周免疫反应与 PD 之间的时间关系尚不清楚。
我们旨在确定外周免疫细胞数量、C 反应蛋白（CRP）与现患和新发 PD 之间的关联。
本研究嵌入了基于人群的鹿特丹研究中。我们在 1990 年至 2016 年期间反复测量了外周免疫细胞数量（白细胞分类计数和血小板计数、中性粒细胞与淋巴细胞比值 [GLR]、血小板与淋巴细胞比值 [PLR]和改良的全身免疫炎症指数 [改良 SII]）和 CRP。参与者持续随访 PD，直至 2018 年。我们分别使用逻辑回归模型和联合模型来评估这些标志物与现患和新发 PD 的关联。模型调整了年龄、性别、吸烟、体重指数和用药情况。结果显示标志物每增加一倍的比值比（OR）和风险比（HR）。
共有 12642 名参与者纳入本研究。参与者的平均年龄（标准差）为 65.1（9.8）岁，57.5%为女性。淋巴细胞计数较高的参与者患现患 PD 的可能性较小（调整 OR：0.34，95%CI 0.17-0.68）。GLR、PLR 和改良 SII 较高的参与者更有可能患现患 PD，但这些影响可由淋巴细胞计数来解释。外周免疫细胞数量和 CRP 与新发 PD 的风险无显著关联。
我们发现淋巴细胞计数较高的参与者患现患 PD 的可能性较小，但我们没有发现外周免疫细胞数量或 CRP 与新发 PD 风险之间存在关联。
