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在一个基于社区的血清阳性成年人样本中，家庭内接触严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与更严重的症状和更强的抗体反应相关。

Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults.

作者信息

Schrock Joshua M, Ryan Daniel T, Saber Rana, Benbow Nanette, Vaught Lauren A, Reiser Nina, Velez Matthew P, Hsieh Ryan, Newcomb Michael, Demonbreun Alexis R, Mustanski Brian, McNally Elizabeth M, D'Aquila Richard, McDade Thomas W

机构信息

Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine.

出版信息

medRxiv. 2021 Mar 12:2021.03.11.21253421. doi: 10.1101/2021.03.11.21253421.

DOI:10.1101/2021.03.11.21253421
PMID:33758903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7987062/
Abstract

Magnitude of SARS-CoV-2 virus exposure may contribute to symptom severity. In a sample of seropositive adults (n=1101), we found that individuals who lived with a known COVID-19 case exhibited greater symptom severity and IgG concentrations compared to individuals who were seropositive but did not live with a known case (P<0.0001).

摘要

接触严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的程度可能会导致症状严重程度。在一个血清反应呈阳性的成年人样本（n = 1101）中，我们发现，与血清反应呈阳性但未与已知新冠病毒病病例同住的个体相比，与已知新冠病毒病病例同住的个体表现出更严重的症状和更高的免疫球蛋白G（IgG）浓度（P<0.0001）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/7987062/66965b0f49f2/nihpp-2021.03.11.21253421-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/7987062/66965b0f49f2/nihpp-2021.03.11.21253421-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41a/7987062/66965b0f49f2/nihpp-2021.03.11.21253421-f0001.jpg

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本文引用的文献

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Ann Epidemiol. 2022 Feb;66:44-51. doi: 10.1016/j.annepidem.2021.10.006. Epub 2021 Oct 31.
2
Patterns and persistence of SARS-CoV-2 IgG antibodies in Chicago to monitor COVID-19 exposure.监测 COVID-19 暴露的芝加哥 SARS-CoV-2 IgG 抗体的模式和持久性。
JCI Insight. 2021 May 10;6(9):146148. doi: 10.1172/jci.insight.146148.
3
SARS-CoV-2 neutralizing antibodies in patients with varying severity of acute COVID-19 illness.
急性 COVID-19 疾病不同严重程度患者中的 SARS-CoV-2 中和抗体。
Sci Rep. 2021 Jan 21;11(1):2062. doi: 10.1038/s41598-021-81629-2.
4
Immune determinants of COVID-19 disease presentation and severity.COVID-19 疾病表现和严重程度的免疫决定因素。
Nat Med. 2021 Jan;27(1):28-33. doi: 10.1038/s41591-020-01202-8. Epub 2021 Jan 13.
5
Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants.职业与重症新型冠状病毒肺炎风险：对120075名英国生物银行参与者的前瞻性队列研究
Occup Environ Med. 2020 Dec 9;78(5):307-14. doi: 10.1136/oemed-2020-106731.
6
COVID-19: Does the infectious inoculum dose-response relationship contribute to understanding heterogeneity in disease severity and transmission dynamics?新型冠状病毒肺炎：传染性接种剂量反应关系有助于理解疾病严重程度和传播动力学的异质性吗？
Med Hypotheses. 2021 Jan;146:110431. doi: 10.1016/j.mehy.2020.110431. Epub 2020 Nov 25.
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