在一个基于社区的血清阳性成年人样本中，家庭内接触严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与更严重的症状和更强的抗体反应相关。
Exposure to SARS-CoV-2 within the household is associated with greater symptom severity and stronger antibody responses in a community-based sample of seropositive adults.
作者信息
Schrock Joshua M, Ryan Daniel T, Saber Rana, Benbow Nanette, Vaught Lauren A, Reiser Nina, Velez Matthew P, Hsieh Ryan, Newcomb Michael, Demonbreun Alexis R, Mustanski Brian, McNally Elizabeth M, D'Aquila Richard, McDade Thomas W
机构信息
Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University.
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
出版信息
medRxiv. 2021 Mar 12:2021.03.11.21253421. doi: 10.1101/2021.03.11.21253421.
Magnitude of SARS-CoV-2 virus exposure may contribute to symptom severity. In a sample of seropositive adults (n=1101), we found that individuals who lived with a known COVID-19 case exhibited greater symptom severity and IgG concentrations compared to individuals who were seropositive but did not live with a known case (P<0.0001).
接触严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的程度可能会导致症状严重程度。在一个血清反应呈阳性的成年人样本（n = 1101）中，我们发现，与血清反应呈阳性但未与已知新冠病毒病病例同住的个体相比，与已知新冠病毒病病例同住的个体表现出更严重的症状和更高的免疫球蛋白G（IgG）浓度（P<0.0001）。
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