Universidade de São Paulo, Faculdade de Medicina, Hospital das Clinicas, Departamento de Dermatologia, Ambulatório das Manifestações Cutâneas das Imunodeficiências Primárias, São Paulo, SP, Brasil.
Rev Soc Bras Med Trop. 2021 Mar 22;54:e0008-2021. doi: 10.1590/0037-8682-0008-2021. eCollection 2021.
We describe the first report of a patient with chronic mucocutaneous candidiasis associated with disseminated and recurrent paracoccidioidomycosis. The investigation demonstrated that the patient had a mannose receptor deficiency, which would explain the patient's susceptibility to chronic infection by Candida spp. and systemic infection by paracoccidioidomycosis. Mannose receptors are responsible for an important link between macrophages and fungal cells during phagocytosis. Deficiency of this receptor could explain the susceptibility to both fungal species, suggesting the impediment of the phagocytosis of these fungi in our patient.
我们描述了首例慢性黏膜皮肤念珠菌病伴播散性和复发性球孢子菌病的患者报告。研究表明，该患者存在甘露糖受体缺陷，这可以解释其易患念珠菌属慢性感染和系统性球孢子菌病感染的原因。甘露糖受体在吞噬作用中是连接巨噬细胞和真菌细胞的重要环节。该受体的缺陷可能解释了对这两种真菌的易感性，表明我们的患者对这些真菌的吞噬作用受到了阻碍。
