Germain M, Gourdeau M, Hébert J
School of Public Health and Community Medicine, Department of Epidemiology, University of Washington, Seattle 98195.
Am J Med Sci. 1994 Apr;307(4):282-3. doi: 10.1097/00000441-199404000-00008.
Chronic mucocutaneous candidiasis (CMC) is usually characterized by onset in childhood and is almost never complicated by deep fungal infection. The authors report two cases of fatal candida meningitis in patients who suffered from mild, adult-onset CMC. The pedigrees suggest an autosomal recessive disorder. In the index cases and in a symptomatic sibling, the immunologic work-up showed a specific cellular deficit as opposed to Candida albicans, as is typical of other forms of CMC. Both families were of French Canadian descent and originated from eastern Quebec. Three other cases of primary candida meningitis in patients of the same ethnic origin are also reported and reviewed. It is suggested that these cases may represent a variant of familial adult-onset CMC, in which there is a striking predisposition to deep infection.
慢性黏膜皮肤念珠菌病（CMC）通常在儿童期发病，几乎从不并发深部真菌感染。作者报告了两例患有轻度成人起病型CMC的患者发生致命性念珠菌性脑膜炎的病例。家系分析提示为常染色体隐性遗传疾病。在索引病例和一名有症状的同胞中，免疫检查显示与白色念珠菌相对应的特异性细胞缺陷，这是其他形式的CMC的典型表现。两个家族均为法裔加拿大人后裔，来自魁北克东部。还报告并回顾了另外三例同种族原发性念珠菌性脑膜炎的病例。有人提出，这些病例可能代表家族性成人起病型CMC的一种变体，其中存在深部感染的显著易感性。
