Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Cell Mol Immunol. 2021 May;18(5):1197-1210. doi: 10.1038/s41423-021-00667-y. Epub 2021 Mar 24.
One of the main goals of vaccine research is the development of adjuvants that can enhance immune responses and are both safe and biocompatible. We explored the application of the natural polymer hyaluronan (HA) as a promising immunological adjuvant for protein-based vaccines. Chemical conjugation of HA to antigens strongly increased their immunogenicity, reduced booster requirements, and allowed antigen dose sparing. HA-based bioconjugates stimulated robust and long-lasting humoral responses without the addition of other immunostimulatory compounds and proved highly efficient when compared to other adjuvants. Due to its intrinsic biocompatibility, HA allowed the exploitation of different injection routes and did not induce inflammation at the inoculation site. This polymer promoted rapid translocation of the antigen to draining lymph nodes, thus facilitating encounters with antigen-presenting cells. Overall, HA can be regarded as an effective and biocompatible adjuvant to be exploited for the design of a wide variety of vaccines.
疫苗研究的主要目标之一是开发能够增强免疫反应、安全且生物相容的佐剂。我们探索了将天然聚合物透明质酸（HA）用作基于蛋白质疫苗的有前途的免疫佐剂。HA 与抗原的化学偶联强烈增强了它们的免疫原性，减少了加强针的需求，并节省了抗原剂量。基于 HA 的生物缀合物在不添加其他免疫刺激性化合物的情况下刺激了强大且持久的体液反应，并与其他佐剂相比证明非常有效。由于其固有生物相容性，HA 允许利用不同的注射途径，并且不会在接种部位引起炎症。这种聚合物促进了抗原向引流淋巴结的快速转移，从而促进了与抗原呈递细胞的相遇。总的来说，HA 可以被视为一种有效的、生物相容的佐剂，可用于设计各种疫苗。
