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本文引用的文献

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Association of Genetics and B Vitamin Status With the Magnitude of Optic Disc Edema During 30-Day Strict Head-Down Tilt Bed Rest.30天严格头低位卧床休息期间遗传学与B族维生素状态对视盘水肿程度的关联
JAMA Ophthalmol. 2019 Oct 1;137(10):1195-1200. doi: 10.1001/jamaophthalmol.2019.3124.
2
The buffering capacity of the brain and optic nerve against spaceflight-associated neuro-ocular syndrome.大脑和视神经对太空飞行相关神经-眼部综合征的缓冲能力。
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15770-15771. doi: 10.1073/pnas.1908865116. Epub 2019 Jul 30.
3
Brain Physiological Response and Adaptation During Spaceflight.脑在航天飞行中的生理反应和适应。
Neurosurgery. 2019 Nov 1;85(5):E815-E821. doi: 10.1093/neuros/nyz203.
4
Brain ventricular volume changes induced by long-duration spaceflight.长期航天飞行引起的脑室内容积变化。
Proc Natl Acad Sci U S A. 2019 May 21;116(21):10531-10536. doi: 10.1073/pnas.1820354116. Epub 2019 May 6.
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Longitudinal Analysis of Quantitative Brain MRI in Astronauts Following Microgravity Exposure.航天员微重力暴露后定量脑 MRI 的纵向分析。
J Neuroimaging. 2019 May;29(3):323-330. doi: 10.1111/jon.12609. Epub 2019 Feb 19.
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Brain Tissue-Volume Changes in Cosmonauts.宇航员脑组织体积的变化
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Optic Disc Edema after 30 Days of Strict Head-down Tilt Bed Rest.严格头低位卧床休息30天后的视盘水肿
Ophthalmology. 2019 Mar;126(3):467-468. doi: 10.1016/j.ophtha.2018.09.042. Epub 2018 Oct 9.
8
Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures.航天飞行引起的颅内高压和视力障碍：病理生理学和对策。
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10
Optic Nerve Sheath Distention as a Protective Mechanism Against the Visual Impairment and Intracranial Pressure Syndrome in Astronauts.视神经鞘扩张作为宇航员视觉损伤和颅内压综合征的一种保护机制。
Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4601-4602. doi: 10.1167/iovs.17-22600.

长期太空飞行后宇航员眼球持续扁平化

Persistent Globe Flattening in Astronauts following Long-Duration Spaceflight.

作者信息

Mader Thomas H, Gibson C Robert, Barratt Michael R, Miller Neil R, Subramanian Prem S, Killer Hanspeter E, Tarver William J, Sargsyan Ashot E, Garcia Kathleen, Hart Stephen F, Kramer Larry A, Riascos Roy, Brunstetter Tyson J, Lipsky William, Wostyn Peter, Lee Andrew G

机构信息

COL(R) US Army, Moab, Utah, USA.

Coastal Eye Associates, Webster, Texas, USA.

出版信息

Neuroophthalmology. 2020 Sep 3;45(1):29-35. doi: 10.1080/01658107.2020.1791189. eCollection 2021.

DOI:10.1080/01658107.2020.1791189
PMID:33762785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7946045/
Abstract

Posterior globe flattening has been well-documented in astronauts both during and after long-duration space flight (LDSF) and has been observed as early as 10 days into a mission on the International Space Station. Globe flattening (GF) is thought to be caused by the disc centred anterior forces created by elevated volume and/or pressure within the optic nerve sheath (ONS). This might be the result of increased intracranial pressure, increased intraorbital ONS pressure from compartmentalisation or a combination of these mechanisms. We report posterior GF in three astronauts that has persisted for 7 years or more following their return from LDSFs suggesting that permanent scleral remodelling may have occurred.

摘要

后极部眼球扁平化在长期太空飞行期间及之后的宇航员中已有充分记录，早在国际空间站任务的第10天就已观察到。眼球扁平化（GF）被认为是由视神经鞘（ONS）内体积和/或压力升高所产生的以视盘为中心的向前作用力引起的。这可能是颅内压升高、因分隔导致眶内ONS压力增加或这些机制共同作用的结果。我们报告了三名宇航员出现后极部GF，在他们从长期太空飞行返回后这种情况持续了7年或更长时间，这表明可能发生了永久性巩膜重塑。