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70岁及以上女性中年时期的睡眠时间与打鼾情况与健康衰老的关系

Sleep Duration and Snoring at Midlife in Relation to Healthy Aging in Women 70 Years of Age or Older.

作者信息

Shi Hongying, Huang Tianyi, Ma Yanan, Eliassen A Heather, Sun Qi, Wang Molin

机构信息

Department of Epidemiology and Health Statistics, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

出版信息

Nat Sci Sleep. 2021 Mar 17;13:411-422. doi: 10.2147/NSS.S302452. eCollection 2021.

Abstract

PURPOSE

Both short and long sleep durations are associated with higher mortality. This study examined the association between sleep duration and overall health among those who survive to older ages.

PARTICIPANTS AND METHODS

In the Nurses' Health Study, participants without major chronic diseases in 1986 and survived to age 70 years or older in 1995-2001 were included. Habitual sleep duration and snoring were self-reported in 1986. Healthy aging was defined as being free of 11 major chronic diseases and having no cognitive impairment, physical impairment, or mental health limitations. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for healthy aging.

RESULTS

Of the 12,304 participants, 1354 (11.0%) achieved healthy aging. We observed a non-linear association between sleep duration and the odds of achieving healthy aging. Compared with women sleeping 7 hours per day, women with longer sleep duration were less likely to achieve healthy aging; there was also a suggestion of lower odds of healthy aging for shorter sleepers, although the associations did not reach statistical significance: the multivariate-adjusted ORs (95% CIs) of healthy aging for those sleeping ≤5, 6, 8, and ≥9 hours were 0.94 (0.70, 1.27), 0.88 (0.76, 1.02), 0.83 (0.72, 0.96), and 0.60 (0.43, 0.84), respectively. Similar non-linear associations were consistently observed for individual dimensions of healthy aging. Regular snoring was associated with 31% lower odds of healthy aging (95% CI: 0.54, 0.88), which was primarily due to lower odds of having no major chronic diseases.

CONCLUSION

Both short and long sleep durations as well as regular snoring at midlife were associated with lower odds of healthy aging in later life.

摘要

目的

睡眠时间过短和过长均与较高的死亡率相关。本研究调查了高寿者的睡眠时间与总体健康状况之间的关联。

参与者与方法

纳入护士健康研究中1986年无重大慢性病且在1995 - 2001年存活至70岁及以上的参与者。1986年通过自我报告获取习惯性睡眠时间和打鼾情况。健康老龄化定义为无11种重大慢性病且无认知障碍、身体功能障碍或心理健康问题。采用逻辑回归估计健康老龄化的比值比(OR)和95%置信区间(CI)。

结果

在12304名参与者中,1354人(11.0%)实现了健康老龄化。我们观察到睡眠时间与实现健康老龄化的几率之间存在非线性关联。与每天睡7小时的女性相比,睡眠时间较长的女性实现健康老龄化的可能性较小;睡眠时间较短者实现健康老龄化的几率也有降低的趋势,尽管这些关联未达到统计学显著性:睡眠时间≤5、6、8和≥9小时者健康老龄化的多变量调整OR(95%CI)分别为0.94(0.70,1.27)、0.88(0.76,1.02)、0.83(0.72,0.96)和0.60(0.43,0.84)。在健康老龄化的各个维度上均一致观察到类似的非线性关联。经常打鼾与健康老龄化几率降低31%相关(95%CI:0.54,0.88),这主要是由于无重大慢性病的几率较低。

结论

中年时睡眠时间过短或过长以及经常打鼾均与晚年健康老龄化几率较低相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3725/7982569/c91e18a2e79c/NSS-13-411-g0001.jpg

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