Yang Yimin, Li Yanhua, Yang Hongmei, Guo Jianxing, Li Nan
Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun, China.
Front Mol Neurosci. 2021 Mar 4;14:631553. doi: 10.3389/fnmol.2021.631553. eCollection 2021.
Parkinson's disease (PD) is the world's second most common neurodegenerative disease that is associated with age. With the aging of the population, patients with PD are increasing in number year by year. Most such patients lose their ability to self-care with disease progression, which brings an incalculable burden to individual families and society. The pathogenesis of PD is complex, and its clinical manifestations are diverse. Therefore, it is of great significance to screen for circulating biomarkers associated with PD to reveal its pathogenesis and develop objective diagnostic methods so as to prevent, control, and treat the disease. In recent years, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are considered to be effective biomarkers for various diseases due to their stability, and resistance to RNAase digestion and extreme conditions in circulating fluids. Here, we review recent advances in the detection of abnormally expressed miRNAs and lncRNAs in PD circulating fluids, and discuss the function and molecular mechanisms of plasma or serum miR-124, miR-132, miR-29, miR-221, miR-7, miR-433, and miR-153 in the regulation and progression of PD. Additionally, application of the differential expression of lncRNAs in circulating fluid in the pathological progression and diagnosis of PD is also reviewed. In short, the determination of abnormally expressed circulating miRNAs and lncRNAs will be valuable for the future diagnosis and treatment of PD.
帕金森病（PD）是全球第二常见的与年龄相关的神经退行性疾病。随着人口老龄化，帕金森病患者数量逐年增加。大多数此类患者随着疾病进展会失去自我护理能力，这给个人家庭和社会带来了难以估量的负担。帕金森病的发病机制复杂，其临床表现多样。因此，筛选与帕金森病相关的循环生物标志物以揭示其发病机制并开发客观诊断方法，从而预防、控制和治疗该疾病具有重要意义。近年来，微小RNA（miRNA）和长链非编码RNA（lncRNA）因其稳定性以及在循环体液中对RNA酶消化和极端条件的耐受性，被认为是各种疾病的有效生物标志物。在此，我们综述帕金森病循环体液中异常表达的miRNA和lncRNA检测的最新进展，并讨论血浆或血清miR-124、miR-132、miR-29、miR-221、miR-7、miR-433和miR-153在帕金森病调控和进展中的功能及分子机制。此外，还综述了循环体液中lncRNA差异表达在帕金森病病理进展和诊断中的应用。简而言之，循环miRNA和lncRNA异常表达的测定对帕金森病未来的诊断和治疗将具有重要价值。
