使用基于粒子图像测速法和基于小波的光流测速法对微通道中凝血过程的血流速度进行测量。
Blood Flow Velocimetry in a Microchannel During Coagulation Using Particle Image Velocimetry and Wavelet-Based Optical Flow Velocimetry.
机构信息
Department of Mechanical and Aerospace Engineering, Case Western Reserve University, Cleveland, OH 44106.
Warren E. Rupp Associate Professor Department of Mechanical and Aerospace Engineering, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106; Department of Biomedical Engineering, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106.
出版信息
J Biomech Eng. 2021 Sep 1;143(9). doi: 10.1115/1.4050647.
Abstract
This article describes novel measurements of the velocity of whole blood flow in a microchannel during coagulation. The blood is imaged volumetrically using a simple optical setup involving a white light source and a microscope camera. The images are processed using particle image velocimetry (PIV) and wavelet-based optical flow velocimetry (wOFV), both of which use images of individual blood cells as flow tracers. Measurements of several clinically relevant parameters such as the clotting time, decay rate, and blockage ratio are computed. The high-resolution wOFV results yield highly detailed information regarding thrombus formation and corresponding flow evolution that is the first of its kind.
摘要
本文描述了一种在凝血过程中测量微通道中全血流动速度的新方法。血液通过简单的光学设置进行体积成像，该设置包括白光光源和显微镜相机。使用粒子图像测速法（PIV）和基于小波的光流测速法（wOFV）对图像进行处理，这两种方法都使用单个血细胞的图像作为流迹示踪剂。计算了几个临床相关参数的测量值，如凝血时间、衰减率和阻塞比。高分辨率 wOFV 结果提供了关于血栓形成和相应流动演变的高度详细信息，这在同类研究中尚属首次。
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