CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China.
School of Electronic and Information Engineering, Soochow University, Suzhou 215006, China.
Sensors (Basel). 2018 Sep 13;18(9):3073. doi: 10.3390/s18093073.
Blood coagulation function monitoring is important for people who are receiving anticoagulation treatment and a portable device is needed by these patients for blood coagulation self-testing. In this paper, a novel smartphone based blood coagulation test platform was proposed. It was developed based on parylene-C coated quartz crystal microbalance (QCM) dissipation measuring and analysis. The parylene-C coating constructed a robust and adhesive surface for fibrin capturing. The dissipation factor was obtained by measuring the frequency response of the sensor. All measured data were sent to a smartphone via Bluetooth for dissipation calculation and blood coagulation results computation. Two major coagulation indexes, activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured on this platform compared with results by a commercial hemostasis system in a clinical laboratory. The measurement results showed that the adjusted R-square (R²) value for APTT and PT measurements were 0.985 and 0.961 respectively. The QCM dissipation method for blood coagulation measurement was reliable and effective and the platform together with the QCM dissipation method was a promising solution for point of care blood coagulation testing.
凝血功能监测对于接受抗凝治疗的人非常重要，这些患者需要便携式设备进行凝血自我检测。本文提出了一种基于智能手机的新型凝血测试平台。该平台基于聚对二甲苯-C 涂层石英晶体微天平（QCM）耗散测量和分析而开发。聚对二甲苯-C 涂层为纤维蛋白捕获构建了一个坚固且具有粘性的表面。通过测量传感器的频率响应获得耗散因子。所有测量数据都通过蓝牙发送到智能手机，用于耗散计算和凝血结果计算。该平台与临床实验室中的商业止血系统相比，测量了两个主要的凝血指标，即活化部分凝血活酶时间（APTT）和凝血酶原时间（PT）。测量结果表明，APTT 和 PT 测量的调整后的 R 平方（R²）值分别为 0.985 和 0.961。用于凝血测量的 QCM 耗散方法是可靠和有效的，该平台和 QCM 耗散方法是即时凝血检测的有前途的解决方案。
