School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, PR China.
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, 430070, PR China.
Carbohydr Polym. 2021 Jun 1;261:117875. doi: 10.1016/j.carbpol.2021.117875. Epub 2021 Feb 27.
Hydrogels are three-dimensional polymeric networks capable of absorbing large amounts of water or biological fluids with the properties resembling natural living tissues. Herein, polyvinyl alcohol (PVA)/N-succinyl chitosan (NSCS)/lincomycin hydrogels for wound dressing were prepared by the freezing/thawing method, then characterized by FTIR, SEM, and TGA. The compression strength, swelling behavior, water retention capacity, antibacterial activity, drug release and cytotoxicity were systematically investigated. The results showed that the introduction of NSCS remarkably enhanced the swelling capacity, leading to the maximum swelling ratio of 19.68 g/g in deionized water. The optimal compression strength of 0.75 MPa was achieved with 30 % NSCS content.Additionally, the incorporation of lincomycin brought a remarkable antibacterial activity against both Escherichia coli and Staphylococcus aureus. Specifically, 77.71 % of Staphylococcus aureus was inhibited with 75 μg/mL lincomycin, while the MTT assay demonstrated the nontoxic nature of the composite hydrogels. In summary, this PVA/NSCS/lincomycin hydrogel showed promising potential for wound dressing.
水凝胶是一种三维高分子网络，具有类似于天然活组织的特性，能够吸收大量的水或生物流体。本文采用冻融法制备了聚乙烯醇（PVA）/N-琥珀酰壳聚糖（NSCS）/林可霉素水凝胶，用于伤口敷料，并通过 FTIR、SEM 和 TGA 进行了表征。系统研究了压缩强度、溶胀行为、保水能力、抗菌活性、药物释放和细胞毒性。结果表明，NSCS 的引入显著提高了水凝胶的溶胀能力，使其在去离子水中的最大溶胀比达到 19.68 g/g。当 NSCS 含量为 30%时，水凝胶获得了最佳的压缩强度为 0.75 MPa。此外，林可霉素的加入赋予了水凝胶对大肠杆菌和金黄色葡萄球菌的显著抗菌活性。具体来说，含有 75μg/mL 林可霉素时，金黄色葡萄球菌的抑制率达到 77.71%，MTT 试验表明复合水凝胶具有无毒的特性。综上所述，这种 PVA/NSCS/lincomycin 水凝胶在伤口敷料方面具有很大的应用潜力。
