Rothschild Foundation Hospital, Paris, France.
CHR Citadelle, Liège, Belgique.
Sci Rep. 2021 Mar 25;11(1):6840. doi: 10.1038/s41598-021-86185-3.
Keratoconus is a highly prevalent corneal disorder characterized by progressive corneal thinning, steepening and irregular astigmatism. To date, pathophysiology of keratoconus development and progression remains debated. In this study, we retrospectively analysed topographic elevation maps from 3227 eyes of 3227 patients (969 keratoconus and 2258 normal eyes) to calculate anterior and posterior corneal surface area. We compared results from normal eyes and keratoconus eyes using the Mann-Whitney U test. The Kruskal-Wallis test was used to compare keratoconus stages according to the Amsler-Krumeich classification. Keratoconus eyes were shown to have statistically significantly larger corneal surface areas, measured at the central 4.0 mm and 8.0 mm, and total corneal diameter. However, no significant increase in corneal surface area was seen with increasing severity of keratoconus. We suggest that these results indicate redistribution, rather than increase, of the corneal surface area with keratoconus severity.
圆锥角膜是一种常见的角膜疾病，其特征为进行性角膜变薄、变陡和不规则散光。迄今为止，圆锥角膜的发病机制和进展仍存在争议。在这项研究中，我们回顾性地分析了 3227 名患者（969 名圆锥角膜和 2258 名正常眼）的 3227 只眼的地形图隆起图，以计算前、后角膜表面积。我们使用曼-惠特尼 U 检验比较了正常眼和圆锥角膜眼的结果。Kruskal-Wallis 检验用于根据 Amsler-Krumeich 分类比较圆锥角膜的分期。结果表明，在中央 4.0mm 和 8.0mm 以及总角膜直径处，圆锥角膜眼的角膜表面积明显更大，且具有统计学意义。然而，随着圆锥角膜严重程度的增加，角膜表面积并没有明显增加。我们认为，这些结果表明，随着圆锥角膜严重程度的增加，角膜表面积的分布发生了变化，而不是增加。
