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mRNA 单价 SARS-CoV-2 疫苗接种一剂可降低无症状 2019 冠状病毒病（COVID-19）养老院居民鼻咽部病毒载量。

Single Dose of an mRNA Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Vaccine Is Associated With Lower Nasopharyngeal Viral Load Among Nursing Home Residents With Asymptomatic Coronavirus Disease 2019 (COVID-19).

机构信息

Department of Medicine, Infectious Diseases Section, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

Department of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

出版信息

Clin Infect Dis. 2021 Sep 15;73(6):e1365-e1367. doi: 10.1093/cid/ciab263.

DOI:10.1093/cid/ciab263
PMID:33768222
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8083695/
Abstract

In nursing home residents with asymptomatic COVID-19 diagnosed through twice-weekly surveillance testing, single-dose BNT162b2 vaccination (Pfizer-BioNTech) was associated with -2.4 mean log10 lower nasopharyngeal viral load than detected in absence of vaccination (P = .004). Since viral load is linked to transmission, single-dose mRNA SARS-CoV-2 vaccination may help control outbreaks.

摘要

在通过每周两次的监测检测诊断出无症状 COVID-19 的养老院居民中，与未接种疫苗相比，单次剂量 BNT162b2 疫苗（辉瑞-生物技术公司）接种使鼻咽病毒载量平均降低了 2.4 个对数 10 （P=0.004）。由于病毒载量与传播有关，单次剂量 mRNA SARS-CoV-2 疫苗接种可能有助于控制疫情爆发。

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