Department of Chemistry, University of Massachusetts, Amherst, MA, 01003, USA.
Center for Bioactive Delivery, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, 01003, USA.
Angew Chem Int Ed Engl. 2021 Jun 1;60(23):12813-12818. doi: 10.1002/anie.202103106. Epub 2021 May 5.
We report here on protein-antibody conjugates (PACs) that are used for antibody-directed delivery of protein therapeutics to specific cells. PACs have the potential to judiciously combine the merits of two prolific therapeutic approaches-biologics and antibody-drug conjugates. We utilize spherical polymer brushes to construct PACs using the combination of two simple and efficient functionally orthogonal click chemistries. In addition to the synthesis and characterization of these nanoparticles, we demonstrate that PACs are indeed capable of specifically targeting cells based on the presence of target antigen on the cell surface to deliver proteins. The potentially broad adaptability of PACs opens up new opportunities for targeted biologics in therapeutics and sensing.
我们在此报告了用于将蛋白治疗药物递送至特定细胞的蛋白-抗体偶联物（PACs）。PAC 具有将两种疗效显著的治疗方法（生物制剂和抗体药物偶联物）巧妙结合的潜力。我们利用球形聚合物刷，通过两种简单且高效的功能正交点击化学的组合构建了 PACs。除了对这些纳米粒子进行合成和表征外，我们还证明 PACs 确实能够基于细胞表面存在靶抗原来特异性靶向细胞以递送蛋白。PACs 的潜在广泛适应性为治疗和传感中的靶向生物制剂开辟了新的机会。
