Golub M S, Gershwin M E, Hurley L S, Hendrickx A G
Division of Internal Medicine, School of Medicine, University of California, Davis.
Am J Clin Nutr. 1988 Jun;47(6):1046-51. doi: 10.1093/ajcn/47.6.1046.
Arrested adolescent growth and sexual maturation are striking symptoms of severe dietary zinc deprivation. More general implications of mild or marginal Zn deficiency during adolescence are not known. Five marginally Zn-deprived (ZD) male monkeys (4 mg Zn/kg diet) were compared with five controls pair fed a diet containing 100 mg Zn/kg during early adolescence. Mean plasma Zn levels were 38% lower in ZD group than in controls when evaluations began. During rapid growth plasma Zn decreased in controls but not ZD animals. ZD animals had delayed onset of accelerated weight gain and linear growth; loss of subcutaneous fat typical of early adolescence did not occur. ZD monkeys required two to three times more trials for both learning and reversal a visual discrimination task. Immune function was depressed 20-30% as reflected in early reduced proliferative response of peripheral lymphocytes and later lower immunoglobulin levels. Marginal dietary Zn deprivation affects growth and function in adolescence without producing frank developmental retardation.
青春期生长停滞和性成熟延迟是严重膳食锌缺乏的显著症状。青春期轻度或边缘性锌缺乏的更广泛影响尚不清楚。将五只边缘性锌缺乏（ZD）雄性猴子（饮食中锌含量为4毫克/千克）与五只在青春期早期配对喂养含100毫克锌/千克饮食的对照猴子进行比较。评估开始时，ZD组的平均血浆锌水平比对照组低38%。在快速生长期间，对照组的血浆锌下降，但ZD动物没有。ZD动物体重加速增加和线性生长的开始延迟；未出现青春期早期典型的皮下脂肪减少。ZD猴子在学习和逆转视觉辨别任务时需要的试验次数是对照组的两到三倍。免疫功能降低了20%-30%，表现为外周淋巴细胞增殖反应早期降低，后期免疫球蛋白水平降低。边缘性膳食锌缺乏会影响青春期的生长和功能，但不会导致明显的发育迟缓。
