Golub M S, Keen C L, Gershwin M E, Styne D M, Takeuchi P T, Ontell F, Walter R M, Hendrickx A G
Department of Internal Medicine, University of California, Davis 95616, USA.
Am J Clin Nutr. 1996 Sep;64(3):274-82. doi: 10.1093/ajcn/64.3.274.
Growth retardation has been associated with zinc deficiency in adolescent human populations, but animal models were not available previously to explore this syndrome. Moderate dietary zinc deprivation (2 micrograms Zn/g diet) was introduced in female rhesus monkeys (Macaca mulatta; n = 10) from the beginning of puberty through menarche. Subgroups of animals (n = 4) continued to be fed the zinc-deficient diet through 45 mo of age (sexual maturity). Reduced weight gain and linear growth and lower plasma zinc concentrations (11.8 +/- 0.6 and 9.2 +/- 0.8 mumol/L in control and zinc-deficient monkeys, respectively) were evident during the premenarcheal growth spurt. Slower skeletal growth, maturation, and mineralization were recorded in the postmenarcheal period and some indicators of sexual maturation were delayed. Food intake was slightly higher in the zinc-deficient group than in controls. These data confirm that adolescent growth and maturation are vulnerable to disruption by moderate dietary zinc deprivation in nonhuman primates.
生长发育迟缓与青少年人群的锌缺乏有关，但此前尚无动物模型来探究这一综合征。从青春期开始直至初潮，对雌性恒河猴（猕猴属；n = 10）实施中度膳食锌剥夺（2微克锌/克日粮）。动物亚组（n = 4）持续喂食缺锌日粮直至45月龄（性成熟）。在初潮前生长突增期间，体重增加和线性生长减缓以及血浆锌浓度降低（对照猴和缺锌猴分别为11.8±0.6和9.2±0.8微摩尔/升）很明显。在初潮后时期记录到骨骼生长、成熟和矿化较慢，并且一些性成熟指标延迟。缺锌组的食物摄入量略高于对照组。这些数据证实，在非人灵长类动物中，青少年生长和成熟易受中度膳食锌剥夺的干扰。
