Murphy D W, Castell D O
Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Am J Gastroenterol. 1988 Jun;83(6):633-6.
Chocolate has been shown to decrease mean basal lower esophageal sphincter (LES) pressure, providing a rationale for the pathogenesis of chocolate-induced reflux symptoms. We assessed the relationship between chocolate ingestion and increased esophageal acid exposure using intraesophageal pH monitoring. Compared with ingestion of a dextrose control solution of similar volume, osmolality, and calories, postprandial ingestion of chocolate resulted in a significant increase in acid exposure in the first postprandial hour in patients with esophagitis. We conclude that this finding supports recommendations that patients with reflux esophagitis abstain from chocolate.
巧克力已被证明会降低食管下括约肌(LES)的平均基础压力,这为巧克力诱发反流症状的发病机制提供了理论依据。我们使用食管内pH监测评估了食用巧克力与食管酸暴露增加之间的关系。与摄入体积、渗透压和热量相似的葡萄糖对照溶液相比,食管炎患者餐后食用巧克力导致餐后第一小时的酸暴露显著增加。我们得出结论,这一发现支持了反流性食管炎患者应避免食用巧克力的建议。