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巧克力与胃灼热:摄入巧克力后食管酸暴露增加的证据。

Chocolate and heartburn: evidence of increased esophageal acid exposure after chocolate ingestion.

作者信息

Murphy D W, Castell D O

机构信息

Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.

出版信息

Am J Gastroenterol. 1988 Jun;83(6):633-6.

PMID:3376917
Abstract

Chocolate has been shown to decrease mean basal lower esophageal sphincter (LES) pressure, providing a rationale for the pathogenesis of chocolate-induced reflux symptoms. We assessed the relationship between chocolate ingestion and increased esophageal acid exposure using intraesophageal pH monitoring. Compared with ingestion of a dextrose control solution of similar volume, osmolality, and calories, postprandial ingestion of chocolate resulted in a significant increase in acid exposure in the first postprandial hour in patients with esophagitis. We conclude that this finding supports recommendations that patients with reflux esophagitis abstain from chocolate.

摘要

巧克力已被证明会降低食管下括约肌(LES)的平均基础压力,这为巧克力诱发反流症状的发病机制提供了理论依据。我们使用食管内pH监测评估了食用巧克力与食管酸暴露增加之间的关系。与摄入体积、渗透压和热量相似的葡萄糖对照溶液相比,食管炎患者餐后食用巧克力导致餐后第一小时的酸暴露显著增加。我们得出结论,这一发现支持了反流性食管炎患者应避免食用巧克力的建议。

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