一家三级学术医疗中心医护人员及其家庭接触者中的新型冠状病毒2型感染：一项纵向队列研究方案
SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study.
作者信息
Ciccone Emily J, Zivich Paul N, Lodge Evans K, Zhu Deanna, Law Elle, Miller Elyse, Taylor Jasmine L, Chung Suemin, Xu Jason, Volfovsky Alexander, Beatty Cherese, Abernathy Haley, King Elise, Garrett Haley E, Markmann Alena J, Rebuli Meghan E, Sellers Subhashini, Weber David J, Reyes Raquel, Alavian Naseem, Juliano Jonathan J, Boyce Ross M, Aiello Allison E
机构信息
Division of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States.
出版信息
JMIR Res Protoc. 2021 Apr 30;10(4):e25410. doi: 10.2196/25410.
BACKGROUND
Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversion in this population is needed.
OBJECTIVE
The primary objectives of this study are to (1) determine the incidence of, and risk factors for, SARS-CoV-2 infection among HCP at a tertiary care medical center and (2) actively monitor PPE use, interactions between study participants via electronic sensors, secondary cases in households, and participant mental health and well-being.
METHODS
To achieve these objectives, we designed a prospective, observational study of SARS-CoV-2 infection among HCP and their household contacts at an academic tertiary care medical center in North Carolina, USA. Enrolled HCP completed frequent surveys on symptoms and work activities and provided serum and nasal samples for SARS-CoV-2 testing every 2 weeks. Additionally, interactions between participants and their movement within the clinical environment were captured with a smartphone app and Bluetooth sensors. Finally, a subset of participants' households was randomly selected every 2 weeks for further investigation, and enrolled households provided serum and nasal samples via at-home collection kits.
RESULTS
As of December 31, 2020, 211 HCP and 53 household participants have been enrolled. Recruitment and follow-up are ongoing and expected to continue through September 2021.
CONCLUSIONS
Much remains to be learned regarding the risk of SARS-CoV-2 infection among HCP and their household contacts. Through the use of a multifaceted prospective study design and a well-characterized cohort, we will collect critical information regarding SARS-CoV-2 transmission risks in the health care setting and its linkage to the community.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/25410.
背景
医护人员（HCP）面临感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒的高风险。虽然个人防护装备（PPE）可能会降低这种风险，但仍需要对该人群中其使用情况及血清转化的其他风险因素进行前瞻性数据收集。
目的
本研究的主要目的是：（1）确定三级医疗中心医护人员中SARS-CoV-2感染的发生率及风险因素；（2）积极监测个人防护装备的使用情况、研究参与者之间通过电子传感器的互动、家庭中的二代病例以及参与者的心理健康和幸福感。
方法
为实现这些目标，我们在美国北卡罗来纳州一家学术性三级医疗中心设计了一项关于医护人员及其家庭接触者中SARS-CoV-2感染的前瞻性观察性研究。登记入组的医护人员频繁完成关于症状和工作活动的调查，并每2周提供血清和鼻拭子样本用于SARS-CoV-2检测。此外，通过一款智能手机应用程序和蓝牙传感器记录参与者之间的互动以及他们在临床环境中的活动。最后，每2周随机选择一部分参与者的家庭进行进一步调查，登记入组的家庭通过家用采集试剂盒提供血清和鼻拭子样本。
结果
截至2020年12月31日，已招募211名医护人员和53名家庭参与者。招募和随访工作正在进行，预计将持续到2021年9月。
结论
关于医护人员及其家庭接触者中SARS-CoV-2感染的风险仍有许多有待了解之处。通过使用多方面的前瞻性研究设计和特征明确的队列，我们将收集有关医疗环境中SARS-CoV-2传播风险及其与社区联系的关键信息。
国际注册报告识别码（IRRID）：DERR1-10.2196/25410。
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