Zou Qian, Si Jiawei, Guo Yatao, Yu Jiayu, Shi Huijuan
Department of Clinical Medicine, Ningxia Medical University, Ningxia, China.
Department of Dermatovenereology, General Hospital of Ningxia Medical University, Ningxia, China.
J Int Med Res. 2021 Mar;49(3):3000605211002381. doi: 10.1177/03000605211002381.
To determine the association between serum visfatin levels and psoriasis and to evaluate the correlation between serum visfatin levels and the severity of psoriasis.
The electronic databases PubMed®, Embase® and the Cochrane Library were searched for articles published from inception to 1 May 2020. Data were extracted and then standard mean differences (SMDs) and 95% confidence intervals (CIs) were calculated for pooled estimates.
A total of 11 studies met the inclusion criteria and were included (448 patients diagnosed with psoriasis and 377 controls). This meta-analysis demonstrated that patients with psoriasis had significantly higher levels of visfatin than the controls (SMD = 0.90, 95% CI 0.52, 1.28). Subgroup analyses showed that differences in serum visfatin levels between the patient group and the control group were associated with ethnicity, Psoriasis Area and Severity Index (PASI) and body mass index. Additionally, a meta-analysis of correlations showed that visfatin levels in patients with psoriasis were positively correlated with PASI ( = 0.51, 95% CI 0.14, 0.75).
This meta-analysis showed that serum visfatin levels in patients with psoriasis were significantly higher than those in the controls and a positive correlation between serum visfatin levels and psoriasis severity was observed.
确定血清内脂素水平与银屑病之间的关联，并评估血清内脂素水平与银屑病严重程度之间的相关性。
检索电子数据库PubMed®、Embase®和Cochrane图书馆，查找从数据库建立至2020年5月1日发表的文章。提取数据，然后计算合并估计值的标准化均数差（SMD）和95%置信区间（CI）。
共有11项研究符合纳入标准并被纳入（448例银屑病患者和377例对照）。该荟萃分析表明，银屑病患者的内脂素水平显著高于对照组（SMD = 0.90，95% CI 0.52，1.28）。亚组分析显示，患者组和对照组血清内脂素水平的差异与种族、银屑病面积和严重程度指数（PASI）以及体重指数有关。此外，相关性的荟萃分析表明，银屑病患者的内脂素水平与PASI呈正相关（r = 0.51，95% CI 0.14，0.75）。
该荟萃分析表明，银屑病患者的血清内脂素水平显著高于对照组，且观察到血清内脂素水平与银屑病严重程度呈正相关。
