School of Life Sciences and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning 110000, China.
Pharmacol Res. 2021 May;167:105576. doi: 10.1016/j.phrs.2021.105576. Epub 2021 Mar 24.
Macrophages are a type of functionally plastic cells that can create a pro-/anti-inflammatory microenvironment for organs by producing different kinds of cytokines, chemokines, and growth factors to regulate immunity and inflammatory responses. In addition, they can also be induced to adopt different phenotypes in response to extracellular and intracellular signals, a process defined as M1/M2 polarization. Growing evidence indicates that glycobiology is closely associated with this polarization process. In this research, we review studies of the roles of glycosylation, glucose metabolism, and key lectins in the regulation of macrophages function and polarization to provide a new perspective for immunotherapies for multiple diseases.
巨噬细胞是一种功能可塑性细胞，通过产生不同类型的细胞因子、趋化因子和生长因子来调节免疫和炎症反应，为器官创造促炎/抗炎的微环境。此外，它们还可以响应细胞外和细胞内信号被诱导采用不同的表型，这个过程被定义为 M1/M2 极化。越来越多的证据表明，糖生物学与这个极化过程密切相关。在这项研究中，我们综述了糖基化、葡萄糖代谢和关键凝集素在调节巨噬细胞功能和极化中的作用的研究，为多种疾病的免疫治疗提供了新的视角。
