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1
Pilot study of recombinant interferon alpha-2a for treatment of infants with bronchiolitis induced by respiratory syncytial virus.重组干扰素α-2a治疗呼吸道合胞病毒所致婴儿细支气管炎的初步研究。
Antimicrob Agents Chemother. 1988 Apr;32(4):589-91. doi: 10.1128/AAC.32.4.589.
2
Bronchiolitis.细支气管炎
Pediatr Rev. 1993 Apr;14(4):134-9. doi: 10.1542/pir.14-4-134.
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Bronchiolitis.
Indian Pediatr. 1986 Oct;23 Suppl:61-8.
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Pulmonary function testing in infants with respiratory syncytial virus bronchiolitis requiring mechanical ventilation.
Pediatr Infect Dis J. 1990 Sep;9(9 Suppl):S108-11. doi: 10.1097/00006454-199009001-00016.
5
Management of respiratory failure in infants with acute viral bronchiolitis.
Am J Dis Child. 1984 Nov;138(11):1071-5. doi: 10.1001/archpedi.1984.02140490071018.
6
Alpha-2A-interferon for treatment of bronchiolitis caused by respiratory syncytial virus.
Pediatr Infect Dis J. 1993 Aug;12(8):653-8. doi: 10.1097/00006454-199308000-00006.
7
Current perspectives on respiratory syncytial virus infection.
Postgrad Med. 1993 Jan;93(1):129-32, 137-8, 141. doi: 10.1080/00325481.1993.11701578.
8
The respiratory syncitial virus and its role in acute bronchiolitis.呼吸道合胞病毒及其在急性细支气管炎中的作用。
Eur J Pediatr. 1992 Sep;151(9):638-51. doi: 10.1007/BF01957564.
9
Production of interferon in respiratory syncytial virus bronchiolitis.呼吸道合胞病毒细支气管炎中干扰素的产生
Arch Dis Child. 1989 Jan;64(1):92-5. doi: 10.1136/adc.64.1.92.
10
Use of extracorporeal membrane oxygenation in the treatment of respiratory syncytial virus bronchiolitis: the national experience, 1983 to 1988.体外膜肺氧合在呼吸道合胞病毒细支气管炎治疗中的应用：1983年至1988年全国经验
J Pediatr. 1990 Mar;116(3):338-42. doi: 10.1016/s0022-3476(05)82817-3.

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1
Age Matters: Key Contributors to Interferon Toxicity in Infants During Influenza Virus Infection.年龄很重要：流感病毒感染期间婴儿干扰素毒性的关键促成因素
Viruses. 2025 Jul 17;17(7):1002. doi: 10.3390/v17071002.
2
Interferons-Implications in the Immune Response to Respiratory Viruses.干扰素——对呼吸道病毒免疫反应的影响
Microorganisms. 2023 Aug 29;11(9):2179. doi: 10.3390/microorganisms11092179.
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Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections.人类 I 型干扰素在呼吸道和新出现病毒感染中的抗病毒作用。
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4
[Not Available].[无可用内容]。
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Role of Type I Interferon (IFN) in the Respiratory Syncytial Virus (RSV) Immune Response and Disease Severity.Ⅰ型干扰素（IFN）在呼吸道合胞病毒（RSV）免疫反应和疾病严重程度中的作用。
Front Immunol. 2019 Mar 26;10:566. doi: 10.3389/fimmu.2019.00566. eCollection 2019.
6
Limited type I interferons and plasmacytoid dendritic cells during neonatal respiratory syncytial virus infection permit immunopathogenesis upon reinfection.新生儿呼吸道合胞病毒感染期间有限的 I 型干扰素和浆细胞样树突状细胞可在再次感染时引发免疫发病机制。
J Virol. 2014 Aug;88(16):9350-60. doi: 10.1128/JVI.00818-14. Epub 2014 Jun 11.
7
Treatment of respiratory syncytial virus infection with recombinant interferon alfa-2a.用重组干扰素α-2a治疗呼吸道合胞病毒感染。
Arch Dis Child. 1993 Oct;69(4):440-2. doi: 10.1136/adc.69.4.440.
8
Bronchiolitis. Origins and optimal management.细支气管炎。起源与最佳管理。
Drugs. 1995 Jun;49(6):885-96. doi: 10.2165/00003495-199549060-00003.
9
The respiratory syncitial virus and its role in acute bronchiolitis.呼吸道合胞病毒及其在急性细支气管炎中的作用。
Eur J Pediatr. 1992 Sep;151(9):638-51. doi: 10.1007/BF01957564.

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Interferon in acute viral infections.
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Evaluation of the human interferon system in viral disease.病毒性疾病中人类干扰素系统的评估。
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Toxicity of interferon.干扰素的毒性
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Convenient assay for interferons.干扰素的便捷检测方法。
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From the National Institute of Allergy and Infectious Diseases. Update on clinical trials with exogenous interferon.
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Antibodies to human leucocyte interferons in cancer patients.癌症患者体内针对人白细胞干扰素的抗体。
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Respiratory syncytial virus in infants and children.婴幼儿呼吸道合胞病毒
Prev Med. 1974 Dec;3(4):473-80. doi: 10.1016/0091-7435(74)90010-3.
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Interferon deficiency syndrome.干扰素缺乏综合征
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9
Interferon in nasal secretions from infants with viral respiratory tract infections.病毒性呼吸道感染婴儿鼻分泌物中的干扰素
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10
Interferon production in children with respiratory syncytial, influenza, and parainfluenza virus infections.呼吸道合胞病毒、流感病毒和副流感病毒感染患儿的干扰素产生情况。
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重组干扰素α-2a治疗呼吸道合胞病毒所致婴儿细支气管炎的初步研究。

Pilot study of recombinant interferon alpha-2a for treatment of infants with bronchiolitis induced by respiratory syncytial virus.

作者信息

Portnoy J, Hicks R, Pacheco F, Olson L

机构信息

Section of Allergy/Immunology Diseases, Children's Mercy Hospital, Kansas City, Missouri.

出版信息

Antimicrob Agents Chemother. 1988 Apr;32(4):589-91. doi: 10.1128/AAC.32.4.589.

DOI:10.1128/AAC.32.4.589
PMID:3377468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172227/
Abstract

Eleven children with bronchiolitis induced by respiratory syncytial virus received 10,000 to 70,000 U of recombinant interferon alpha-2a per kg of body weight per day. None developed signs of toxicity, and all but one developed an antiviral state following treatment. Interferon alpha-2a appears to be safe for infants with bronchiolitis. Its efficacy for the treatment of this condition remains to be determined.

摘要

11名因呼吸道合胞病毒引起细支气管炎的儿童，每天每千克体重接受10000至70000单位的重组干扰素α-2a治疗。无一例出现毒性迹象，除1例之外，所有患儿在治疗后均进入抗病毒状态。干扰素α-2a对患有细支气管炎的婴儿似乎是安全的。其对这种病症的治疗效果仍有待确定。