重组干扰素α-2a治疗呼吸道合胞病毒所致婴儿细支气管炎的初步研究。
Pilot study of recombinant interferon alpha-2a for treatment of infants with bronchiolitis induced by respiratory syncytial virus.
作者信息
Portnoy J, Hicks R, Pacheco F, Olson L
机构信息
Section of Allergy/Immunology Diseases, Children's Mercy Hospital, Kansas City, Missouri.
出版信息
Antimicrob Agents Chemother. 1988 Apr;32(4):589-91. doi: 10.1128/AAC.32.4.589.
Abstract
Eleven children with bronchiolitis induced by respiratory syncytial virus received 10,000 to 70,000 U of recombinant interferon alpha-2a per kg of body weight per day. None developed signs of toxicity, and all but one developed an antiviral state following treatment. Interferon alpha-2a appears to be safe for infants with bronchiolitis. Its efficacy for the treatment of this condition remains to be determined.
摘要
11名因呼吸道合胞病毒引起细支气管炎的儿童，每天每千克体重接受10000至70000单位的重组干扰素α-2a治疗。无一例出现毒性迹象，除1例之外，所有患儿在治疗后均进入抗病毒状态。干扰素α-2a对患有细支气管炎的婴儿似乎是安全的。其对这种病症的治疗效果仍有待确定。
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