Medway School of Pharmacy, University of Kent, Medway Campus, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, United Kingdom.
CIPER Centre for Innovation and Process Engineering Research, Kent ME4 4TB, UK.
Adv Drug Deliv Rev. 2021 Jun;173:60-69. doi: 10.1016/j.addr.2021.03.007. Epub 2021 Mar 26.
The present review aims at identifying the key progress points that have been made on the use of 3D printing to manufacture microneedles in the past 3 years. The advances in the field of photopolymerization and extrusion-based 3D printing are outlined. The study revealed that the printing resolution and the material properties are the two critical parameters that have the most influential effect on the outcome of every microneedle printing endeavour. Finally, the authors attempt to estimate the impact of 3D printing on the transdermal drug delivery market.
本综述旨在确定过去 3 年来在使用 3D 打印制造微针方面取得的关键进展点。概述了光聚合和基于挤出的 3D 打印领域的进展。研究表明,打印分辨率和材料性能是对每一次微针打印效果影响最大的两个关键参数。最后,作者试图估计 3D 打印对透皮药物输送市场的影响。