甲状腺激素对脂肪组织柔韧性的影响。
Effect of Thyroid Hormones on Adipose Tissue Flexibility.
作者信息
Volke Lisa, Krause Kerstin
机构信息
Medical Department III-Endocrinology, Nephrology, and Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
Department of Medicine, University of Leipzig, Leipzig, Germany.
出版信息
Eur Thyroid J. 2021 Mar;10(1):1-9. doi: 10.1159/000508483. Epub 2020 Jul 9.
Abstract
The recruitment and activation of energy-consuming brown adipocytes is currently considered as potential therapeutic approach to combat obesity. Thyroid hormones (TH) significantly contribute to full thermogenic capacity of brown adipocytes. A number of recent studies suggest that TH also induce the recruitment of brown adipocytes in white adipose depots, a process known as browning. In this review, we will summarize underlying mechanisms by which TH mediate brown adipose tissue activity and white adipose tissue browning. Furthermore, we will discuss the relevance of TH-induced white adipose tissue browning for thermoregulation.
摘要
目前，耗能棕色脂肪细胞的募集和激活被认为是对抗肥胖的潜在治疗方法。甲状腺激素（TH）对棕色脂肪细胞的完全产热能力有显著贡献。最近的一些研究表明，TH还能诱导白色脂肪库中棕色脂肪细胞的募集，这一过程称为“褐变”。在这篇综述中，我们将总结TH介导棕色脂肪组织活性和白色脂肪组织褐变的潜在机制。此外，我们还将讨论TH诱导的白色脂肪组织褐变与体温调节的相关性。
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