Guan Mengqi, Zhu Shoujun, Li Shanshan
Department of Dermatology and Venerology, The First Hospital of Jilin University, Changchun, China.
Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, China.
Front Bioeng Biotechnol. 2021 Mar 11;9:661214. doi: 10.3389/fbioe.2021.661214. eCollection 2021.
Melanoma is an aggressive type of skin cancer with increasing incidence and high mortality rates worldwide. However, there is still a lack of efficient and resolutive treatment strategies, particularly in clinical settings. Currently, nanomedicine, an emerging area in the medical field, is being widely investigated in small animal models to afford melanoma theranostics. However, several problems, such as tumor heterogeneity, and drug resistance treatment with a single therapy, remain unresolved. Previous reviews have primarily focused on monotherapy for melanoma in the context of nanomedicine. In this review article, we summarize the recent progress in the application of nanomedicine for melanoma treatment, with particular attention to combination therapy based on nanomedicine to achieve optimized therapeutic output for melanoma treatment. In addition, we also highlight the fluorescence-guided strategies for intraoperative melanoma detection, especially in the near-infrared imaging window with greatly improved imaging contrast and penetration depth.
黑色素瘤是一种侵袭性皮肤癌，在全球范围内发病率不断上升且死亡率很高。然而，仍然缺乏有效且决定性的治疗策略，尤其是在临床环境中。目前，纳米医学作为医学领域的一个新兴领域，正在小动物模型中被广泛研究以提供黑色素瘤的诊疗方法。然而，一些问题，如肿瘤异质性以及单一疗法的耐药性治疗，仍未得到解决。以往的综述主要集中在纳米医学背景下黑色素瘤的单一疗法。在这篇综述文章中，我们总结了纳米医学在黑色素瘤治疗应用中的最新进展，特别关注基于纳米医学的联合疗法以实现黑色素瘤治疗的优化治疗效果。此外，我们还强调了术中黑色素瘤检测的荧光引导策略，特别是在具有大大提高的成像对比度和穿透深度的近红外成像窗口。
