Yu Minhua, Xu Dan, Lan Lan, Tu Mengqi, Liao Rufang, Cai Shuhan, Cao Yiyuan, Xu Liying, Liao Meiyan, Zhang Xiaochun, Xiao Shu-Yuan, Li Yirong, Xu Haibo
Departments of Radiology (M.Y., D.X., L.L., M.T., R.L., Y.C., L.X., M.L., X.Z., H.X.), Critical Care Medicine (S.C.), Pathology (S.Y.X.), and Laboratory Medicine (Y.L.), Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan 430071, China; and Department of Pathology, University of Chicago Medicine, Chicago, Ill (S.Y.X.).
Radiol Cardiothorac Imaging. 2020 Apr 23;2(2):e200126. doi: 10.1148/ryct.2020200126. eCollection 2020 Apr.
To compare radiologic characteristics of coronavirus disease 2019 (COVID-19) pneumonia at thin-section CT on admission between patients with mild and severe disease.
Seventy patients with COVID-19 pneumonia who were admitted to Zhongnan Hospital of Wuhan University between January 20, 2020 and January 27, 2020 were enrolled. On the basis of the World Health Organization guidelines, 50 patients were categorized with the mild form and 20 with the severe form based on clinical conditions. Imaging features, clinical, and laboratory data were reviewed and compared.
Patients with the severe form (median age, 65 years; interquartile range [IQR]: 54.75-75.00 years) were older than those with the mild form of disease (median age, 42.5 years; IQR: 32.75-58.50 years) ( < .001). Patients with the severe form of disease had more lung segments involved (median number of segments: 17.5 vs 7.5, ≤ .001) and also larger opacities (median number of segments with opacities measuring 3 cm to less than 50% of the lung segment: 5.5 vs 2.0, = .006; ≥ 50% of lung segment: 7.5 vs 0.0, < .001). They also had more interlobular septal thickening (75% vs 28%, < .001), higher prevalence of air bronchograms (70% vs 32%, = .004), and pleural effusions (40% vs 14%, = .017).
Ground-glass opacities with or without consolidation in a peripheral and basilar predominant distribution were the most common findings in COVID-19 pneumonia. Patients with the severe form of the disease had more extensive opacification of the lung parenchyma than did patients with mild disease. Interlobular septal thickening, air bronchograms, and pleural effusions were also more prevalent in severe COVID-19.© RSNA, 2020.
比较2019冠状病毒病（COVID-19）肺炎患者入院时薄层CT的影像学特征，区分轻症和重症患者。
纳入2020年1月20日至1月27日期间在武汉大学中南医院收治的70例COVID-19肺炎患者。根据世界卫生组织指南，依据临床情况将50例患者归类为轻症，20例为重症。对影像学特征、临床和实验室数据进行回顾和比较。
重症患者（中位年龄65岁；四分位间距[IQR]：54.75 - 75.00岁）比轻症患者（中位年龄42.5岁；IQR：32.75 - 58.50岁）年龄更大（P <.001）。重症患者累及的肺段更多（中位肺段数：17.5对7.5，P ≤.001），且实变更明显（直径3 cm至小于肺段50%的实变肺段中位数量：5.5对2.0，P =.006；≥肺段50%：7.5对0.0，P <.001）。他们还伴有更多的小叶间隔增厚（75%对28%，P <.001）、空气支气管征发生率更高（70%对32%，P =.004）以及胸腔积液（40%对14%，P =.017）。
以磨玻璃影为主、有或无实变，以外周和基底部分布为主是COVID-19肺炎最常见的表现。重症患者肺实质的实变范围比轻症患者更广泛。小叶间隔增厚、空气支气管征和胸腔积液在重症COVID-19中也更常见。© RSNA，2020。
