维生素 B2 补充剂预防偏头痛的效果：系统评价和荟萃分析。

Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis.

机构信息

Department of Nursing, College of Medicine, National Cheng Kung University, , Tainan City, Taiwan.

Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City, Taiwan.

出版信息

Nutr Neurosci. 2022 Sep;25(9):1801-1812. doi: 10.1080/1028415X.2021.1904542. Epub 2021 Mar 29.

DOI:10.1080/1028415X.2021.1904542

PMID:33779525

Abstract

OBJECTIVE

Migraine is a common disease worldwide and migraine prevention is primarily currently based on pharmaceuticals. The mechanism of Vitamin B2 may positively contribute to migraine. This systematic review and meta-analysis aimed to evaluate the impact of Vitamin B2 supplementation on the days, duration, frequency, and pain score of the migraine attack.

METHODS

: The PRISMA guideline was used for the studying process. Five electronic databases, PubMed, Embase, Cochrane, CINAHL, and CEPS were searched from 1990 to March 2019. The search terms were Vitamin B2, migraine, and prophylactic. A meta-analysis was performed using Comprehensive Meta-Analysis (CMA) version.

RESULTS

: Nine articles were included in systemic review and finally meta-analysis. Eight randomized controlled trials and one controlled clinical trial with 673 subjects were analyzed using meta-analysis. Vitamin B2 supplementation significantly decreased migraine days (= .005, = 89%), duration (= .003, = 0), frequency (= .001, = 65%), and pain score (= .015, = 84%).

CONCLUSIONS

A pooled analysis of available randomized controlled clinical trials demonstrated that Vitamin B2 400 mg/day for three months supplementation had significant effect on days, duration, frequency, and pain score of migraine attacks.

摘要

目的

偏头痛是一种全球性的常见疾病，目前偏头痛的预防主要基于药物。维生素 B2 的作用机制可能对偏头痛有积极的影响。本系统评价和荟萃分析旨在评估维生素 B2 补充剂对偏头痛发作天数、持续时间、频率和疼痛评分的影响。

方法

采用 PRISMA 指南进行研究。从 1990 年到 2019 年 3 月，我们在五个电子数据库（PubMed、Embase、Cochrane、CINAHL 和 CEPS）中搜索了维生素 B2、偏头痛和预防这三个关键词。使用 Comprehensive Meta-Analysis（CMA）版本进行荟萃分析。

结果

共纳入了 9 篇系统性综述文章，最终进行了荟萃分析。使用荟萃分析分析了 8 项随机对照试验和 1 项对照临床试验，共 673 名受试者。维生素 B2 补充剂显著减少了偏头痛发作的天数（= 0.005，= 89%）、持续时间（= 0.003，= 0）、频率（= 0.001，= 65%）和疼痛评分（= 0.015，= 84%）。