Tao Yingxuan, Wu Murong, Su Boyao, Lin Heng, Li Qianzi, Zhong Tian, Xiao Ying, Yu Xi
Faculty of Medicine, Macau University of Science and Technology, Avenida Wai Long Taipa, Macau.
Nutrients. 2025 May 27;17(11):1821. doi: 10.3390/nu17111821.
: Anxiety, stress, and sleep disturbances significantly affect overall health. Research suggests that vitamins B1 and B2 may play a role in mood regulation and neuroprotection. This study aimed to investigate the effects of vitamin B1 and B2 supplementation in alleviating anxiety and stress and improving sleep quality. : This study was a parallel randomized, double-blind, placebo-controlled clinical trial. Participants (n = 43) were randomized to receive one of the following two interventions: 100 mg of vitamin B1 and 100 mg of vitamin B2 or placebo. Intervention outcomes were assessed at baseline and week four, including SAS (Self-Rating Anxiety Scale), PSS (Perceived Stress Scale), PSQI (Sleep Quality Index), ESS (Sleepiness Scale), and measurement of urinary vitamin B1 and B2 levels. : After four weeks, urinary vitamin B1 levels increased from 158 ± 108.9 ng to 1333.1 ± 1204.5 ng ( < 0.01), and urinary vitamin B2 levels increased from 308.0 ± 198.3 ng to 6123.2 ± 4847.2 ng in the supplement group ( < 0.01). The PSS scores decreased significantly in the supplement group from 21.5 ± 4.1 to 15.5 ± 4.5 ( < 0.05), while the placebo group showed a change from 20.3 ± 4.3 to 19.8 ± 5.5. Vitamins B1 and B2 did not have a significant effect on anxiety improvement ( > 0.05). The PSQI scores decreased in the supplement group from 8.0 ± 3.12 to 6.3 ± 2.0 ( < 0.05), while the placebo group worsened from 5.7 ± 2.7 to 7.4 ± 2.9. Meanwhile, the ESS scores in the supplement group decreased from 13.0 ± 3.4 to 9.1 ± 3.9 ( < 0.05), demonstrating a significant improvement compared to the placebo group. : The clinical trial findings demonstrated that while vitamin B1 and B2 supplements helped reduce stress, enhance sleep, and reduce sleepiness, they had no discernible impact on reducing anxiety. Future studies should focus on the long-term effects of vitamin B1 and B2 supplements, exploring the combined effects of combined vitamin B1 and B2 medications for the treatment of stress and sleep disorders.
焦虑、压力和睡眠障碍会显著影响整体健康。研究表明，维生素B1和B2可能在情绪调节和神经保护方面发挥作用。本研究旨在探讨补充维生素B1和B2在缓解焦虑和压力以及改善睡眠质量方面的效果。
本研究为平行随机、双盲、安慰剂对照临床试验。参与者（n = 43）被随机分为接受以下两种干预措施之一：100毫克维生素B1和100毫克维生素B2或安慰剂。在基线和第四周评估干预结果，包括SAS（自评焦虑量表）、PSS（感知压力量表）、PSQI（睡眠质量指数）、ESS（嗜睡量表）以及尿中维生素B1和B2水平的测量。
四周后，补充组尿中维生素B1水平从158±108.9纳克增加到1333.1±1204.5纳克（<0.01），尿中维生素B2水平从308.0±198.3纳克增加到6123.2±4847.2纳克（<0.01）。补充组的PSS评分从21.5±4.1显著降至15.5±4.5（<0.05），而安慰剂组从20.3±4.3变为19.8±5.5。维生素B1和B2对改善焦虑无显著影响（>0.05）。补充组的PSQI评分从8.0±3.12降至6.3±2.0（<0.05），而安慰剂组从5.7±2.7恶化至7.4±2.9。同时，补充组的ESS评分从13.0±3.4降至9.1±3.9（<0.05），与安慰剂组相比有显著改善。
临床试验结果表明，虽然补充维生素B1和B2有助于减轻压力、改善睡眠和减少嗜睡，但对减轻焦虑没有明显影响。未来的研究应关注维生素B1和B2补充剂的长期影响，探索维生素B1和B2联合用药治疗压力和睡眠障碍的综合效果。
