Department Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Public Health Agency of Canada, Guelph, ON, Canada.
Zoonoses Public Health. 2021 Nov;68(7):719-736. doi: 10.1111/zph.12769. Epub 2021 Mar 29.
Salmonella infections are a major human health concern. In the elderly and immunocompromised, infections can be life-threatening and may require antibiotic therapy. Where antibiotic therapy is required, antimicrobials of choice include fluoroquinolones and extended-spectrum cephalosporins (ESC). The aim of this study is to utilize data from the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS) to compare the prevalence of Salmonella serovars between broiler chicken and turkey flocks across Canada, and to gain an understanding of the prevalence of resistance to antimicrobials categorized as important to human health. There were 1,596 Salmonella isolates obtained from 514 broiler chicken flocks, and 659 Salmonella isolates obtained from 217 turkey flocks (2013-2018). All isolates were obtained from pooled faecal samples. Among broiler chicken flocks, the top three serovars were Kentucky (n = 573, 36%), Enteritidis (n = 314, 20%) and Heidelberg (n = 127, 8%). Resistance to ceftriaxone among Salmonella ser. Kentucky decreased from 27% in 2013 to 22% in 2018. There was no resistance among Salmonella ser. Enteritidis reported until 2018 when one isolate from British Columbia was resistant to ampicillin, streptomycin, sulphisoxazole and tetracycline. Salmonella ser. Heidelberg resistance to ceftriaxone decreased from 19% in 2013 to 14% in 2018. Among turkey flocks the top three serovars were Uganda (n = 109, 16.5%), Hadar (n = 85, 12%) and Muenchen (n = 66, 10%). No isolates of Salmonella ser. Uganda or Salmonella ser. Muenchen were resistant to any β-lactams. Salmonella ser. Hadar (34/81, 42%) exhibited resistance to ampicillin. There was no resistance to quinolones among turkey isolates. Emerging resistance among Salmonella ser. Enteritidis, and resistance to β-lactams and fluoroquinolones among Salmonella ser. Kentucky from broilers are cause for concern as these classes of antimicrobials are important for treatment of salmonellosis.
沙门氏菌感染是一个严重的人类健康问题。在老年人和免疫功能低下者中，感染可能危及生命，可能需要抗生素治疗。在需要抗生素治疗的情况下，首选的抗菌药物包括氟喹诺酮类和扩展谱头孢菌素（ESC）。本研究旨在利用加拿大抗菌药物耐药性监测综合计划（CIPARS）的数据，比较加拿大各地肉鸡和火鸡群中沙门氏菌血清型的流行率，并了解对人类健康重要的分类抗菌药物的耐药率。2013 年至 2018 年，从 514 个肉鸡鸡群中获得了 1596 株沙门氏菌分离株，从 217 个火鸡群中获得了 659 株沙门氏菌分离株。所有分离株均来自混合粪便样本。在肉鸡鸡群中，排名前三的血清型分别为肯塔基州（n=573，36%）、肠炎沙门氏菌（n=314，20%）和海德堡沙门氏菌（n=127，8%）。2013 年至 2018 年间，肯塔基州沙门氏菌对头孢曲松的耐药率从 27%下降到 22%。直到 2018 年，不列颠哥伦比亚省的一个分离株对氨苄西林、链霉素、磺胺二甲嘧啶和四环素耐药，才报告肠炎沙门氏菌没有耐药性。2013 年至 2018 年间，海德堡沙门氏菌对头孢曲松的耐药率从 19%下降到 14%。在火鸡鸡群中，排名前三的血清型分别为乌干达（n=109，16.5%）、哈达尔（n=85，12%）和慕尼黑（n=66，10%）。没有分离到对任何β-内酰胺类药物耐药的乌干达沙门氏菌或慕尼黑沙门氏菌。哈达尔沙门氏菌（34/81，42%）对氨苄西林耐药。火鸡分离株对氟喹诺酮类药物无耐药性。肠炎沙门氏菌的耐药性不断出现，以及来自肉鸡的肯塔基州沙门氏菌对β-内酰胺类和氟喹诺酮类药物的耐药性令人担忧，因为这些类别的抗菌药物对治疗沙门氏菌病很重要。
