Kanai A, Tanaka M, Ishii R, Nakajima A
Am J Ophthalmol. 1982 May;93(5):600-6. doi: 10.1016/s0002-9394(14)77375-1.
Of 281 eyes that had had Sato's anterior-posterior radial keratotomy for myopia or myopic astigmatism, 80 (50 patients) underwent follow-up examinations ten to 20 years later. Sixty of the 80 eyes had bullous keratopathy. The onset of this disease occurred when the patient was about 40 years old, regardless of the patient's age at the time of surgery. Seven corneal buttons were obtained from patients with bullous keratopathy who required penetrating keratoplasty. Light and electron microscopy disclosed subepithelial bullae, degenerate or absent Bowman's zone, and thickened Descemet's membrane. Flattened fibroblastic endothelial cells were observed in three of the seven cases. This type of radial keratotomy surgery seems to produce severe corneal decompensation many years later, possibly as a result of damage from the corneal incisions in combination with endothelial losses from aging.
在接受佐藤前后放射状角膜切开术治疗近视或近视散光的281只眼中，80只眼（50例患者）在10至20年后接受了随访检查。80只眼中有60只发生了大疱性角膜病变。这种疾病的发病发生在患者大约40岁时，与手术时患者的年龄无关。从需要穿透性角膜移植术的大疱性角膜病变患者身上获取了7个角膜纽扣组织。光镜和电镜检查发现上皮下大疱、Bowman层退变或缺失以及Descemet膜增厚。在7例中的3例中观察到扁平的成纤维细胞样内皮细胞。这种类型的放射状角膜切开术似乎在多年后会导致严重的角膜失代偿，可能是角膜切口损伤与衰老导致的内皮细胞损失共同作用的结果。
