Department of Ultrasound, Children's Hospital of Fudan University, Shanghai, China.
Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.
PLoS One. 2021 Mar 29;16(3):e0248827. doi: 10.1371/journal.pone.0248827. eCollection 2021.
Several recent studies demonstrated that lung ultrasound could achieve desired diagnostic accuracy for transient tachypnea of the neonate (TTN). However, the diagnostic performance of lung ultrasound for TTN has not been systematically studied to date. This meta-analysis aimed to investigate the performance of lung ultrasound in diagnosing TTN. The relevant literature was searched in PubMed, Medline, the Cochrane Library, and Embase databases without any restriction in terms of language and time until January 31, 2021. Studies that assessed the diagnostic performance of lung ultrasound for TTN were included. Seven studies with 1514 participants were summarized. The lung ultrasound provided more accurate performance for diagnosing TTN with pooled sensitivity and specificity of 0.67 [95% confidence interval (CI) = 0.63-0.71] and 0.97 (95% CI = 0.95-0.98), respectively. A higher summarized area under the summary receiver operating characteristic curve was observed as 0.9906. Lower sensitivity and area under the curve (AUC) of B-lines for TTN were observed as 0.330 (95% CI = 0.27-0.38) and 0.5000, respectively. Lung ultrasound provided highly accurate AUC, sensitivity, and specificity in detecting TTN. Large-scale studies are warranted in the future to confirm these results.
几项最近的研究表明，肺部超声能够达到诊断新生儿暂时性呼吸急促（TTN）所需的准确性。然而，迄今为止，尚未对肺部超声诊断 TTN 的性能进行系统研究。本荟萃分析旨在探讨肺部超声在诊断 TTN 中的性能。在 2021 年 1 月 31 日之前，我们在 PubMed、Medline、Cochrane 图书馆和 Embase 数据库中搜索了相关文献，没有任何语言和时间限制。纳入了评估肺部超声对 TTN 诊断性能的研究。总结了 7 项涉及 1514 名参与者的研究。肺部超声对 TTN 的诊断性能更准确，其汇总敏感性和特异性分别为 0.67（95%置信区间 [CI] = 0.63-0.71）和 0.97（95% CI = 0.95-0.98）。观察到的汇总受试者工作特征曲线下面积较高，为 0.9906。B 线对 TTN 的敏感性和曲线下面积（AUC）较低，分别为 0.330（95% CI = 0.27-0.38）和 0.5000。肺部超声在检测 TTN 方面具有较高的 AUC、敏感性和特异性。未来需要进行大规模研究来证实这些结果。
