Department of Anthropology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237, Lodz, Poland.
The Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Sci Rep. 2021 Mar 29;11(1):7029. doi: 10.1038/s41598-021-86521-7.
Associations between body characteristics (body composition: fat mass, muscle mass, cell, and water mass as well as body proportion-BMI), the 2D:4D digit ratio, and the concentrations of cortisol and vitamin (25-OH)D among Polish children have not been studied before. A total of 133 (73 girls and 60 boys) healthy Polish children aged 7-11 years were examined. The investigation was divided into three parts: measuring (the length of the second and fourth fingers in both hands, body composition, and body height and mass), questionnaires (socioeconomic status), and laboratory investigations (25-OH vitamin D and cortisol concentrations in saliva measured with ELISA methods). Boys with digit ratios below 1 had lower vitamin D concentration than those with digit ratios equal to or higher than 1 (Z = - 2.33; p = 0.019). Only boys with the male-typical pattern of 2D:4D digit ratio tended to have a lower 25-OH vitamin D concentration in saliva. Thus, it might indicate an effect of prenatal programming on the concentrations of steroid hormones in later life. Neither vitamin D, 2D:4D digit ratio nor the cortisol level was associated with the body components or proportions. More studies are needed to evaluate the molecular and genetic background of this phenomenon.
之前尚未研究过波兰儿童的身体特征（身体成分：脂肪量、肌肉量、细胞量和水量以及身体比例——BMI）、2D:4D 指比率与皮质醇和维生素（25-OH）D 浓度之间的关联。共检查了 133 名（73 名女孩和 60 名男孩）健康的波兰 7-11 岁儿童。调查分为三部分：测量（双手第二和第四指的长度、身体成分以及身高和体重）、问卷调查（社会经济地位）和实验室研究（用 ELISA 法测量唾液中的 25-OH 维生素 D 和皮质醇浓度）。2D:4D 指比率低于 1 的男孩的维生素 D 浓度低于比率等于或高于 1 的男孩（Z=-2.33;p=0.019）。只有具有男性典型 2D:4D 指比率模式的男孩唾液中 25-OH 维生素 D 浓度较低。因此，这可能表明产前编程对生命后期类固醇激素浓度的影响。维生素 D、2D:4D 指比率和皮质醇水平均与身体成分或比例无关。需要进行更多的研究来评估这种现象的分子和遗传背景。
