Quartero A O, de Wit N J, Lodder A C, Numans M E, Smout A J, Hoes A W
Department of General Practice, Universiteit Utrecht, The Netherlands.
Dig Dis Sci. 1998 Sep;43(9):2028-33. doi: 10.1023/a:1018803129779.
Functional dyspepsia is a common disorder with a diverse pathophysiological background, but the role of motility disorders in functional dyspepsia remains unclear. We aimed to quantify the relationship between disturbed gastric emptying and functional dyspepsia, using a meta-analytic approach. Through a structured literature search of Medline and Embase from 1983 to 1996, we selected all studies in which scintigraphic solid-phase gastric emptying was measured in both functional dyspeptic patients and controls. Seventeen studies involving 868 dyspeptic patients and 397 controls were pooled. Gastric emptying in patients with functional dyspepsia was 1.46 (1.23-1.69) times slower than controls; the proportion of patients with abnormally slow emptying was either 37% (34-40%, simple numeric pooling) or 39% (29-49%, weighted pooling). We conclude that gastric emptying of solids in patients with functional dyspepsia is 1.5 times slower than in healthy controls and that a significant delay of emptying is present in almost 40% of patients with functional dyspepsia.
功能性消化不良是一种具有多种病理生理背景的常见疾病，但动力障碍在功能性消化不良中的作用仍不明确。我们旨在采用荟萃分析方法量化胃排空障碍与功能性消化不良之间的关系。通过对1983年至1996年的Medline和Embase进行结构化文献检索，我们选择了所有对功能性消化不良患者和对照组均进行闪烁扫描法测量固相胃排空的研究。汇总了17项涉及868例消化不良患者和397例对照的研究。功能性消化不良患者的胃排空比对照组慢1.46（1.23 - 1.69）倍；排空异常缓慢的患者比例为37%（34 - 40%，简单数字合并）或39%（29 - 49%，加权合并）。我们得出结论，功能性消化不良患者的固体胃排空比健康对照组慢1.5倍，并且几乎40%的功能性消化不良患者存在明显的排空延迟。
