Suzuki T, Nakaya M, Nakamura T, Itoh Z
Nihon Heikatsukin Gakkai Zasshi. 1985 Apr;21(2):139-49. doi: 10.1540/jsmr1965.21.139.
Cisapride strongly stimulates gastrointestinal motor activity simultaneously from stomach to jejunum in the interdigestive state. The contractile pattern in the stomach was quite similar to that of the natural interdigestive mingrating contractions (IMC) in all respects, frequency, contractile force, and coordination between the gastric body and antrum. However, the cisapride-induced IMC-like contractions in the stomach did not migrate along the small intestine, nor were accompanied by an increase of plasma motilin concentration. Furthermore, both motilin and cisapride, given during the period of phase III, did not affect the phase III activity, but carbachol abruptly stopped phase III activity if it was given during phase III activity. On the contrary, cisapride-induced contractions in the stomach are completely inhibited by atropine, pentagastrin, CCK-octapeptide, but not by secretin. These findings provide additional evidence to indicate that the cisapride-induced contractions in the stomach are identical with the natural IMC in the respect of reactons to hormonal substances. No noticeable side effects were observed. In conclusion, cisapride is a unique compound to initiate IMC-like contractions in the stomach, but the contractions were not accompanied by an increase in plasma motilin concentration and did not migrate the small intestine.
西沙必利在消化间期能强烈刺激胃肠道运动，使胃至空肠同步活动。胃的收缩模式在频率、收缩力以及胃体和胃窦之间的协调性等各方面，都与自然消化间期移行性收缩（IMC）极为相似。然而，西沙必利诱导的胃内IMC样收缩并不沿小肠移行，也未伴有血浆胃动素浓度升高。此外，在Ⅲ期给予胃动素和西沙必利，均不影响Ⅲ期活动，但在Ⅲ期活动时给予卡巴胆碱会突然终止Ⅲ期活动。相反，西沙必利诱导的胃收缩完全受阿托品、五肽胃泌素、CCK-八肽抑制，但不受促胰液素抑制。这些发现进一步证明，西沙必利诱导的胃收缩在对激素物质的反应方面与自然IMC相同。未观察到明显副作用。总之，西沙必利是一种能引发胃内IMC样收缩的独特化合物，但这种收缩并不伴有血浆胃动素浓度升高，也不向小肠移行。
