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壳聚糖纳米颗粒与甲硝唑对实验性贾第虫病感染仓鼠的治疗效果

Therapeutic Effect of Chitosan Nanoparticles and Metronidazole in Treatment of Experimentally Giardiasis Infected Hamsters.

作者信息

El-Gendy Alaaeldin Mohammed Labib, Mohammed Mohammed Abdelmoneim Abdelhamid, Ghallab Marwa Mohammed Ibrahim, Abdel Aziz Marwa Omar, Ibrahim Shereen Mahmoud

机构信息

Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Department of Medical Parasitology, Faculty of Medicine, Kafr-Elshiekh University, Kafr-Elshiekh, Egypt.

出版信息

Iran J Parasitol. 2021 Jan-Mar;16(1):32-42. doi: 10.18502/ijpa.v16i1.5509.

DOI:10.18502/ijpa.v16i1.5509
PMID:33786045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7988670/
Abstract

BACKGROUND

The present study aimed to assess the therapeutic effect of chitosan nanoparticles and metronidazole against as well as evaluate the efficacy of loading metronidazole on chitosan nanoparticles.

METHODS

This study was carried out at medical Parasitology Department, Faculty of Medicine, Zagazig University and Theodor Bilharz Research institute (TBRI) from February 2019 to February 2020 on 45 hamsters. They were divided into 5 groups 9 hamsters each: Group A non-infected hamsters, Group B infected control group, Group C, D and E infected with and treated with Chitosan nanoparticles (CsNPs), metronidazole (MTZ) and metronidazole-loaded chitosan nanoparticles (MTZ-CsNPs) respectively.

RESULTS

The highest percentage of reduction in the cyst and trophozoite counts were in group that received MTZ-CsNPs (94.69%, 94.29%). Lower percentages of reduction were recorded for MTZ treated group (90.15%, 89.52%) and CsNPs treated group (63.64%, 75.24%). Histopathological examination showed marked healing of intestinal mucosa after treatment with MTZ-CsNPs.

CONCLUSION

CsNPs showed a therapeutic effect against infection in hamsters. Loading of metronidazole on chitosan nanoparticles enhanced therapeutic effect of both CsNPs as well as metronidazole.

摘要

背景

本研究旨在评估壳聚糖纳米颗粒和甲硝唑对[具体寄生虫名称未给出]的治疗效果，并评估壳聚糖纳米颗粒负载甲硝唑的疗效。

方法

本研究于2019年2月至2020年2月在扎加齐格大学医学院医学寄生虫学系和西奥多·比尔哈兹研究所（TBRI）对45只仓鼠进行。它们被分为5组，每组9只仓鼠：A组为未感染仓鼠，B组为感染对照组，C组、D组和E组感染[具体寄生虫名称未给出]，分别用壳聚糖纳米颗粒（CsNPs）、甲硝唑（MTZ）和负载甲硝唑的壳聚糖纳米颗粒（MTZ-CsNPs）进行治疗。

结果

接受MTZ-CsNPs治疗的组中，[具体寄生虫名称未给出]囊肿和滋养体计数减少的百分比最高（分别为94.69%、94.29%）。MTZ治疗组（分别为90.15%、89.52%）和CsNPs治疗组（分别为63.64%、75.24%）的减少百分比较低。组织病理学检查显示，MTZ-CsNPs治疗后肠黏膜有明显愈合。

结论

CsNPs对仓鼠的[具体寄生虫名称未给出]感染显示出治疗效果。壳聚糖纳米颗粒负载甲硝唑增强了CsNPs和甲硝唑的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/e167e2be4246/IJPA-16-32-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/12658fb5ec55/IJPA-16-32-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/89ba1942a39e/IJPA-16-32-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/1cfe16395baf/IJPA-16-32-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/e167e2be4246/IJPA-16-32-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/12658fb5ec55/IJPA-16-32-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/89ba1942a39e/IJPA-16-32-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/1cfe16395baf/IJPA-16-32-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7af/7988670/e167e2be4246/IJPA-16-32-g004.jpg

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