Elgadir M Abd, Uddin Md Salim, Ferdosh Sahena, Adam Aishah, Chowdhury Ahmed Jalal Khan, Sarker Md Zaidul Islam
Department of Pharmacology and Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA, 42300 Bandar Puncak Alam, Selangor, Malaysia.
Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan Campus, 25200 Kuantan, Pahang, Malaysia.
J Food Drug Anal. 2015 Dec;23(4):619-629. doi: 10.1016/j.jfda.2014.10.008. Epub 2014 Dec 4.
Chitosan is a promising biopolymer for drug delivery systems. Because of its beneficial properties, chitosan is widely used in biomedical and pharmaceutical fields. In this review, we summarize the physicochemical and drug delivery properties of chitosan, selected studies on utilization of chitosan and chitosan-based nanoparticle composites in various drug delivery systems, and selected studies on the application of chitosan films in both drug delivery and wound healing. Chitosan is considered the most important polysaccharide for various drug delivery purposes because of its cationic character and primary amino groups, which are responsible for its many properties such as mucoadhesion, controlled drug release, transfection, in situ gelation, and efflux pump inhibitory properties and permeation enhancement. This review can enhance our understanding of drug delivery systems particularly in cases where chitosan drug-loaded nanoparticles are applied.
壳聚糖是一种用于药物递送系统的很有前景的生物聚合物。由于其有益特性，壳聚糖在生物医学和制药领域得到广泛应用。在本综述中，我们总结了壳聚糖的物理化学和药物递送特性、壳聚糖及基于壳聚糖的纳米颗粒复合材料在各种药物递送系统中的应用研究，以及壳聚糖膜在药物递送和伤口愈合方面的应用研究。壳聚糖因其阳离子特性和伯氨基而被认为是用于各种药物递送目的的最重要的多糖，这些特性赋予了它许多性能，如粘膜粘附性、药物控释、转染、原位凝胶化、外排泵抑制性能和渗透增强。本综述能够增进我们对药物递送系统的理解，特别是在应用载有壳聚糖药物纳米颗粒的情况下。
