Kholodenko B N
Research Institute for Technology and Safety of Drugs, Moscow, USSR.
FEBS Lett. 1988 May 23;232(2):383-6. doi: 10.1016/0014-5793(88)80775-0.
The flux through a metabolic pathway can be controlled by external signals from the environment. These signals are formally described as changes in external parameters, such as concentrations of external metabolites (substrates or effectors) or physical parameters, e.g. temperature, pH, ionic strength. It was proved that the response coefficient of the flux (or of the concentration) to a change in an external parameter is the weighted average of external elasticities of pathway enzymes towards this parameter; weight factors are the control coefficients of corresponding enzymes. As compared with the previously known relationships these ones are applicable to the more common case of parameters acting on more than one enzyme. Along with other applications, the use of the obtained relationships for control analysis of moiety-conserved cycles is considered.
代谢途径的通量可由来自环境的外部信号控制。这些信号被正式描述为外部参数的变化，例如外部代谢物（底物或效应物）的浓度或物理参数，如温度、pH值、离子强度。已证明通量（或浓度）对外部参数变化的响应系数是途径酶对该参数的外部弹性的加权平均值；权重因子是相应酶的控制系数。与先前已知的关系相比，这些关系适用于作用于一种以上酶的参数的更常见情况。除了其他应用外，还考虑了将所得关系用于部分守恒循环的控制分析。
