Kholodenko B N, Erlikh L I
Biofizika. 1989 Sep-Oct;34(5):802-7.
Basic quantitative parameters of control in a metabolic system are considered: control coefficients of enzymes with respect to metabolic fluxes and concentrations, and in the case when there are conservation laws, the response coefficients of metabolic fluxes and concentrations to changes in the conserved sums of metabolite concentrations (e. g. conserved moieties). Relationships are obtained which generalize the well known connectivity relations for the case of metabolites binding by conservation laws. Additional relationships are obtained which complement the set of connectivity relations up to the complete system of equations for determining all the control coefficients. The control coefficients are expressed through the enzyme elasticity coefficients, steady state metabolic fluxes and concentrations. Formulas are derived which express response coefficients of flux and concentrations through the enzyme control and elasticity coefficients and metabolite concentrations.
酶对代谢通量和浓度的控制系数，以及在存在守恒定律的情况下，代谢通量和浓度对代谢物浓度守恒和变化（例如守恒部分）的响应系数。得到了一些关系，这些关系推广了代谢物通过守恒定律结合的情况下著名的连通性关系。还得到了其他关系，这些关系补充了连通性关系集，直至确定所有控制系数的完整方程组。控制系数通过酶弹性系数、稳态代谢通量和浓度来表示。推导了通过酶控制系数、弹性系数和代谢物浓度来表示通量和浓度响应系数的公式。
