Basante-Romo Mónica, Gutiérrez-M Jose Oscar, Camargo-Amado Rubén
Physicochemistry of Bio and Nanomaterials Research Group, School of Chemical Engineering, Universidad del Valle, Calle 13 # 100-00, Cali, Colombia.
Farmacología UNIVALLE Research Group, School of Medicine, Universidad del Valle, Calle 4B # 36-00, Cali, Colombia.
Heliyon. 2021 Mar 16;7(3):e06514. doi: 10.1016/j.heliyon.2021.e06514. eCollection 2021 Mar.
Modified titanium dioxide (m-TiONPs) is a novel photocatalytic nanomaterial. Its level of toxicity was evaluated to be used in photodynamic treatment for cervical cancer. In the toxicity studies (Irwin test, acute and repeated doses (10 days)), female albino Swiss Webster (CFW) mice, 28 days old were used; the m-TiONPs was administered in single 300, 600 and 5,000 mg/kg of body weight (b.w) doses injected in the peritoneal zone. No adverse events or mortality were produced. Daily intraperitoneal doses of 300 and 600 mg/kg b.w every 24 h for 10 days did not produce adverse effects or mortality. There were no abnormal clinical signs or behavioral changes (neurological or physiological) in any of the mice. All organs exhibited normal architecture, and histological studies determined that m-TiONPs does not produce changes in the cells or tissues. Based on the test results, it is concluded that the m-TiONPs has not a toxic effect in doses equal to or less than 5,000 mg/kg b.w.
改性二氧化钛（m-TiONPs）是一种新型的光催化纳米材料。对其毒性水平进行了评估，以用于宫颈癌的光动力治疗。在毒性研究（欧文试验、急性和重复剂量（10天））中，使用了28日龄的雌性白化瑞士韦伯斯特（CFW）小鼠；m-TiONPs以300、600和5000毫克/千克体重（b.w）的单次剂量注射到腹腔区域。未产生不良事件或死亡。连续10天每天腹腔注射300和600毫克/千克体重的剂量未产生不良反应或死亡。任何小鼠均未出现异常临床体征或行为变化（神经或生理方面）。所有器官均表现出正常结构，组织学研究确定m-TiONPs不会引起细胞或组织的变化。根据测试结果，得出结论：剂量等于或小于5000毫克/千克体重时，m-TiONPs没有毒性作用。
