Piu Chan, MD, PhD, Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China, E-mail:
J Nutr Health Aging. 2021;25(4):410-415. doi: 10.1007/s12603-020-1522-1.
Frailty is known to be influenced by genetics, however, little evidence on the association of Apolipoprotein E (ApoE) genotype and frailty exists which we aim to investigate.
This study is a cross-sectional analysis from a prospective longitudinal study cohort.
Community-dwelling individuals aged 55 years and older from Beijing region in China.
A total of 3,569 older adults with a mean age of 75.06(±6.79) years were included. We investigated the association between ApoE polymorphism and frailty syndrome using the frailty index (FI) and frailty phenotype (including association with individual components of the frailty phenotype). Logistic regressions were performed to investigate the relation between ApoE variants and frailty.
There was no significant association between ApoE variants and frailty as assessed by the FI. In the age and sex-adjusted model, compared to the ApoE e3/e3 carriers ApoE e4 carriers had almost 1.5 times higher odds of being frail as assessed by the frailty phenotype. However, the significance was lost on the model with adjustment for cognitive impairment. Compared to the ApoE e3/e3 carriers ApoE e4 carriers had almost two times higher odds of fatigue. ApoE e4 heterozygotes had higher odds of fatigue compared to ApoE e4 non-carriers. No significant association was found between ApoE variants and other components of frailty phenotype.
Our findings do not support an association between ApoE genotype and frailty irrespective of the frailty assessment tools. Fatigue in older adults is the only component of frailty phenotype influenced by ApoE genotype.
众所周知，衰老是受遗传因素影响的，但目前关于载脂蛋白 E（ApoE）基因型与衰弱之间的关联证据很少，我们旨在对此进行研究。
这是一项来自前瞻性纵向研究队列的横断面分析。
来自中国北京地区的 55 岁及以上的社区居民。
共纳入 3569 名平均年龄为 75.06(±6.79)岁的老年人。我们使用衰弱指数（FI）和衰弱表型（包括与衰弱表型各组成部分的关联）来研究 ApoE 多态性与衰弱综合征之间的关系。采用逻辑回归来研究 ApoE 变体与衰弱之间的关系。
FI 评估的 ApoE 变体与衰弱之间没有显著关联。在年龄和性别调整模型中，与 ApoE e3/e3 携带者相比，ApoE e4 携带者衰弱表型评估的衰弱风险几乎高出 1.5 倍。然而，在调整认知障碍的模型中，这种关联消失了。与 ApoE e3/e3 携带者相比，ApoE e4 携带者疲劳的风险几乎高出两倍。ApoE e4 杂合子与 ApoE e4 非携带者相比，疲劳的风险更高。ApoE 变体与衰弱表型的其他组成部分之间没有显著关联。
无论使用何种衰弱评估工具，我们的研究结果均不支持 ApoE 基因型与衰弱之间存在关联。老年人的疲劳是受 ApoE 基因型影响的衰弱表型的唯一组成部分。
