炎症性肺病患者循环骨桥蛋白水平升高，与 SARS-CoV-2 感染无关。
High levels of circulating osteopontin in inflammatory lung disease regardless of Sars-CoV-2 infection.
机构信息
Department of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, Università del Piemonte Orientale, Novara, Italy.
Center for Translational Research on Autoimmune and Allergic Disease-CAAD, Università del Piemonte Orientale, Novara, Italy.
出版信息
EMBO Mol Med. 2021 May 7;13(5):e14124. doi: 10.15252/emmm.202114124. Epub 2021 Mar 31.
This study independently confirms increased levels of osteopontin in COVID-19 patients but also suggests that osteopontin cannot be used as a biomarker of SARS-CoV-2 infection, as elevated levels of circulating osteopontin are found in inflammatory lung disease regardless of SARS-CoV-2 infection.
本研究独立证实了 COVID-19 患者的骨桥蛋白水平升高，但也表明骨桥蛋白不能作为 SARS-CoV-2 感染的生物标志物，因为无论是否存在 SARS-CoV-2 感染，循环骨桥蛋白水平升高都与炎症性肺部疾病有关。
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