Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Department of Orthopaedics, Tenth People's Hospital, Tongji University, Shanghai, 200072, China.
J Mater Sci Mater Med. 2021 Mar 31;32(4):37. doi: 10.1007/s10856-021-06508-8.
Cartilage is an avascular tissue with low cellularity and insufficient self-repair response. In clinical practice, a large articular cartilage defect is usually fixed by cartilage transplantation. Importantly, the fast repair process has been demanded postoperatively in the area between the host cartilage and the transplanted cartilage. In the past few years, magnetic nanoparticles have drawn great attention due to their biocompatible, biodegradable, and nontoxic properties. In addition, the nanoparticles can easily pass through the cell plasma membrane and increase the cellular uptake efficiency. Here, a therapeutic drug delivery strategy was proposed for cartilage repair. The prepared kartogenin (KGN)-conjugated magnetic nanocarriers (KGN@NCs) promoted the viability of chondrocytes in vitro. In a rat model of cartilage transplantation, intra-articularly delivered KGN@NCs generated cartilage with a flat surface and a high level of aggrecan in vivo. Notably, KGN@NCs were also capable of improving the pain-related motor functions. They promoted the motor functional parameters including the print area and intensity to restore to a normal level compared with the single KGN. Therefore, these therapeutic drug nanocarriers provided the potential for cartilage repair.
软骨是一种无血管组织，细胞密度低，自我修复反应不足。在临床实践中，通常采用软骨移植来固定大的关节软骨缺损。重要的是，术后宿主软骨和移植软骨之间的区域要求快速修复。在过去的几年中，由于磁性纳米粒子具有生物相容性、可生物降解和无毒的特性，因此引起了极大的关注。此外，这些纳米粒子可以很容易地穿过细胞膜，提高细胞摄取效率。在这里，提出了一种用于软骨修复的治疗性药物输送策略。制备的姜黄素（KGN）偶联磁纳米载体（KGN@NCs）促进了体外软骨细胞的活力。在软骨移植的大鼠模型中，关节内递送的 KGN@NCs 在体内产生了具有平坦表面和高水平聚集蛋白聚糖的软骨。值得注意的是，KGN@NCs 还能够改善与疼痛相关的运动功能。与单独的 KGN 相比，它们促进了包括印迹面积和强度在内的运动功能参数恢复到正常水平。因此，这些治疗性药物纳米载体为软骨修复提供了潜力。
