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Cognitive deficits in people who have recovered from COVID-19.新冠康复者的认知缺陷。
EClinicalMedicine. 2021 Sep;39:101044. doi: 10.1016/j.eclinm.2021.101044. Epub 2021 Jul 23.
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Adapted sickness behavior - Why it is not enough to limit the COVID-19 spread?适应性疾病行为——为何限制新冠病毒传播并不够？
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Microvascular Injury in the Brains of Patients with Covid-19.新冠病毒肺炎患者脑部的微血管损伤
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Remembering seasonal coronaviruses.铭记季节性冠状病毒。
Science. 2020 Dec 11;370(6522):1272-1273. doi: 10.1126/science.abf4860.
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COVID-19 mortality risk for older men and women.COVID-19 对老年男性和女性的死亡率风险。
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Similarities and differences between the 'cytokine storms' in acute dengue and COVID-19.急性登革热和 COVID-19 中“细胞因子风暴”的异同。
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Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.严重和危重新冠肺炎中的细胞因子升高：快速系统评价、荟萃分析，并与其他炎症综合征比较。
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Neuropathology of patients with COVID-19 in Germany: a post-mortem case series.德国 COVID-19 患者的神经病理学：一项尸检病例系列研究。
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Viral presence and immunopathology in patients with lethal COVID-19: a prospective autopsy cohort study.在致死性 COVID-19 患者中的病毒存在和免疫病理学：一项前瞻性尸检队列研究。
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The major genetic risk factor for severe COVID-19 is inherited from Neanderthals.严重 COVID-19 的主要遗传风险因素来自尼安德特人。
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小胶质细胞与 COVID-19 严重程度之间的关联：“双打击”假说。

The link between microglia and the severity of COVID-19: The "two-hit" hypothesis.

机构信息

Université de Lorraine, LCOMS/Neurotoxicologie Alimentaire et Bioactivité, Metz, France.

Department of Population Health (DoPH), Luxembourg Institute of Health (LIH), Nutrition and Health Research Group, Strassen, Luxembourg.

出版信息

J Med Virol. 2021 Jul;93(7):4111-4113. doi: 10.1002/jmv.26984. Epub 2021 Apr 14.

DOI:10.1002/jmv.26984
PMID:33788265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8250886/
Abstract

Neurological manifestations constitute a serious cause of severe coronavirus disease 2019 (COVID‐19). Microglial hyperactivation by the two‐hit process. Severe COVID‐19 patients carry pre‐activated microglia following a first immune challenge. Exaggerated response of sensitized microglia to COVID‐19, the second immune challenge.

摘要

神经系统表现是导致严重 2019 冠状病毒病（COVID‐19）的一个严重原因。双打击过程导致小胶质细胞过度激活。严重 COVID‐19 患者在首次免疫挑战后携带预先激活的小胶质细胞。致敏小胶质细胞对 COVID‐19 的过度反应，即第二次免疫挑战。