Pierre P, Langendries A, Vaerman J P
Catholic University of Louvain, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
Immunol Lett. 1988 May;18(1):51-5. doi: 10.1016/0165-2478(88)90069-7.
Rats were immunized three times with cholera toxin via the intraintestinal or intravenous route, and their respective biliary secretory IgA (sIgA) or serum IgG antibodies were affinity-purified on a cholera toxin immunoabsorbent. On a molar basis, the sIgA antibodies were roughly seven-fold more efficient than IgG antibodies in neutralizing cholera toxin in the ligated intestinal loop assay. Various explanations for this difference in neutralizing capacity are proposed.
通过肠内或静脉途径用霍乱毒素对大鼠进行三次免疫，然后将它们各自的胆汁分泌型IgA（sIgA）或血清IgG抗体在霍乱毒素免疫吸附剂上进行亲和纯化。在结扎肠袢试验中，以摩尔计，sIgA抗体中和霍乱毒素的效率比IgG抗体高约七倍。针对这种中和能力差异提出了各种解释。
