Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pediatr Blood Cancer. 2021 Jun;68(6):e29030. doi: 10.1002/pbc.29030. Epub 2021 Mar 31.
The cumulative burden of chronic health conditions as childhood cancer survivors transition to adult health care and insurance systems is unknown. We estimated the cumulative burden (N = 4612 survivors, 625 controls) in the St. Jude Lifetime Cohort. At 18 and 26 years old, survivors experienced (per 100 individuals) an average of 22.3 (95% confidence interval [CI]: 17.2-27.4) and 40.3 (95% CI: 34.8-45.8) disabling conditions versus 3.5 (95% CI: 2.0-5.0) and 5.7 (95% CI: 3.7-7.7) in controls, and 128.7 (95% CI: 119.5-137.8) and 240.5 (95% CI: 229.9-251.0) lower severity conditions versus 12.4 (95% CI: 8.9-16.0) and 51.3 (95% CI: 43.1-59.4) in controls. Survivors experience a high cumulative burden at key health care transition ages, underscoring the need to optimize access to care.
儿童癌症幸存者在过渡到成人医疗保健和保险系统时，慢性健康状况的累积负担是未知的。我们估计了圣裘德终身队列中的累积负担（N=4612 名幸存者，625 名对照者）。在 18 岁和 26 岁时，与对照组的 3.5（95%置信区间[CI]：2.0-5.0）和 5.7（95%CI：3.7-7.7）相比，幸存者经历了平均 22.3（95%CI：17.2-27.4）和 40.3（95%CI：34.8-45.8）残疾状况，而对照组的 128.7（95%CI：119.5-137.8）和 240.5（95%CI：229.9-251.0）严重程度较低的状况与对照组的 12.4（95%CI：8.9-16.0）和 51.3（95%CI：43.1-59.4）相比。幸存者在关键的医疗保健过渡年龄经历了高累积负担，这突显了优化获得医疗保健机会的必要性。
