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用于通过移动设备对慢性眼表炎症进行远程监测和治疗的智能隐形眼镜及透明热敷贴片。

Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles.

作者信息

Jang Jiuk, Kim Joohee, Shin Haein, Park Young-Geun, Joo Byung Jun, Seo Hunkyu, Won Jong-Eun, Kim Dai Woo, Lee Chang Young, Kim Hong Kyun, Park Jang-Ung

机构信息

Nano Science Technology Institute, Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.

Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.

出版信息

Sci Adv. 2021 Mar 31;7(14). doi: 10.1126/sciadv.abf7194. Print 2021 Mar.

DOI:10.1126/sciadv.abf7194
PMID:33789904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8011975/
Abstract

Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.

摘要

能够监测人体生理信号以提供生物医学信息的可穿戴电子设备，在可持续的个人健康管理方面引起了广泛关注。在此，我们报告了一项针对慢性眼表炎症（OSI）的无线监测和治疗的软质智能隐形眼镜及皮肤可附着治疗设备的人体试验。作为一种诊断设备，这种智能隐形眼镜能够利用石墨烯场效应晶体管实时测量泪液中基质金属蛋白酶-9（一种OSI生物标志物）的浓度。作为一种治疗设备，我们还制造了一种可贴合附着在人眼睑上的可拉伸透明热贴片。诊断和治疗设备都可以通过智能手机进行无线通信，从而实现OSI的即时诊断和自动热疗。此外，使用活体动物和人体受试者的体内测试证实了它们作为一种非侵入性移动医疗解决方案的良好生物相容性和可靠性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/1dfd09c5ed77/abf7194-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/29e028554522/abf7194-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/0ce2e534d282/abf7194-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/00965df6f2ac/abf7194-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/f106f9b3217f/abf7194-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/1dfd09c5ed77/abf7194-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/29e028554522/abf7194-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/0ce2e534d282/abf7194-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/00965df6f2ac/abf7194-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/f106f9b3217f/abf7194-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3409/8011975/1dfd09c5ed77/abf7194-f5.jpg

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