Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Brazil.
Graduate Program in Health Science, Federal University of Sergipe, Aracaju, Brazil.
Front Public Health. 2021 Mar 9;9:581618. doi: 10.3389/fpubh.2021.581618. eCollection 2021.
Information on how coronavirus disease 2019 (COVID-19) mortality is related to population characteristics in low- and middle-income countries is still limited. We described the deaths from COVID-19 in Sergipe state, Northeast Brazil, from April 2 to June 27, 2020. For this purpose, we conducted a study composed of (i) a case series study of all deaths due to COVID-19 and (ii) a population-based study to verify the behavior of the mortality and case-fatality rates (CFR) related to COVID-19. Data from 605 deaths due to COVID-19 were used to describe the characteristics of individuals with the disease, as well as the differences in gender, age, and comorbidities. Additionally, population data were extracted to estimate the mortality and CFR by population stratum. We also performed an adjusted CFR analysis including a time lag of 14 days between the onset of symptoms and reporting deaths. Of the 605 patients included in this study, 321 (53.1%) were males and the median age was 67.0 years. Most patients ( = 447, 73.9%) who died from COVID-19 had at least one pre-existing clinical condition. The mortality rate was 29.3 deaths per 100,000 inhabitants and the crude CRF was 2.6% (95% CI 2.4-2.8). CFR was higher in males (3.1%, 95% CI 2.8-3.4; < 0.001) and people aged ≥60 years (14.2%, 95% CI 13.0-15.6; = 0.042). About 25% of patients died during the first 24-h post-hospital admission. The adjusted CFR for a 14-day time lag was ~2-fold higher than the crude CFR over the study period.
关于 2019 年冠状病毒病（COVID-19）死亡率与中低收入国家人口特征的关系的信息仍然有限。我们描述了 2020 年 4 月 2 日至 6 月 27 日巴西东北部塞尔希培州的 COVID-19 死亡情况。为此，我们进行了一项研究，包括（i）所有 COVID-19 死亡的病例系列研究和（ii）一项基于人群的研究，以验证 COVID-19 死亡率和病死率（CFR）的变化。使用 605 例 COVID-19 死亡病例的数据来描述该病患者的特征，以及性别、年龄和合并症的差异。此外，还提取了人口数据，以按人口分层估计死亡率和 CFR。我们还进行了调整后的 CFR 分析，包括症状出现和报告死亡之间的 14 天时间滞后。在这项研究中，纳入了 605 例患者，其中 321 例（53.1%）为男性，中位年龄为 67.0 岁。死于 COVID-19 的大多数患者（=447 例，73.9%）至少有一种先前存在的临床疾病。死亡率为每 10 万人中有 29.3 人死亡，粗病死率为 2.6%（95%CI 2.4-2.8）。男性（3.1%，95%CI 2.8-3.4；<0.001）和年龄≥60 岁的人群（14.2%，95%CI 13.0-15.6；=0.042）的病死率较高。大约 25%的患者在住院后 24 小时内死亡。在研究期间，调整后的 CFR 为 14 天时间滞后时的粗 CFR 的约 2 倍。
